Results 51 to 60 of about 7,453,923 (244)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Post-transcriptional regulation during stress
, 2022 To remain competitive, cells exposed to stress of varying duration, rapidity of onset, and intensity, have to balance their expenditure on growth and proliferation versus stress protection. To a large degree dependent on the time scale of stress exposure,
Hernández-Elvira, Mariana +3 more
core +1 more source
Post-transcriptional regulation in the developing embryo
, 2019 Embryonic development is critically reliant on well-defined spatial and temporal patterns of gene expression. These patterns are often achieved through the regulation of gene expression at the mRNA level.
Fernandes, Sara Maria Ferreira
core +1 more source
From the proteomic point of view: Integration of adaptive changes to iron deficiency in plants
Current Plant Biology, 2016 Knowledge about the proteomic adaptations to iron deficiency in plants may contribute to find possible new research targets in order to generate crop plants that are more tolerant to iron deficiency, to increase the iron content or to enhance the ...
Hans-Jörg Mai, Petra Bauer
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Post-transcriptional regulation of miRNA biogenesis [PDF]
, 2019 MicroRNAs (miRNAs) are short non-coding RNA molecules of ~22 nt in length that function as regulators of gene expression. They bind to the 3’ UTR of target mRNAs in a non-perfect complimentary manner, leading to either their degradation or ...
Downie, Angela
core +1 more source
The role of long non-coding RNAs in genome formatting and expression
Frontiers in Genetics, 2015 Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization ...
Pierre-Olivier eAngrand +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model. [PDF]
PLoS Computational Biology, 2017 Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of new blood vessels. Besides an increase in the production of pro-angiogenic signals such as vascular endothelial growth factor (VEGF), hypoxia also stimulates ...
Chen Zhao +2 more
doaj +1 more source