Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA
Genomics, Proteomics & Bioinformatics, 2017 Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.
Iain M. Dykes, Costanza Emanueli
doaj +1 more source
AU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity. [PDF]
, 2021 Genome integrity must be tightly preserved to ensure cellular survival and to deter the genesis of disease. Endogenous and exogenous stressors that impose threats to genomic stability through DNA damage are counteracted by a tightly regulated DNA damage ...
Teotia, Varsha +6 more
core +1 more source
Post-transcriptional regulation of gene expression by Unr
, 2015 Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been ...
Emma C. Anderson (10134833) +2 more
core +5 more sources
Transcriptional Regulation and Combinatorial Genetic Logic in Synthetic Bacterial Circuits [PDF]
, 2008 We engineered several synthetic regulatory circuits to study transcriptional regulation in bacteria. We developed a new technique for DNA construction, built and characterized in vivo a library of genetic logic gates, examined the role of genetic noise ...
Cox, Robert Sidney, III
core +1 more source
Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition
Non-Coding RNA, 2018 Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leading ...
Almudena Expósito-Villén +2 more
doaj +1 more source
A Genome-Scale Atlas Reveals Complex Interplay of Transcription and Translation in an Archaeon
mSystems, 2023 The scale of post-transcriptional regulation and the implications of its interplay with other forms of regulation in environmental acclimation are underexplored for organisms of the domain Archaea.
Alan P. R. Lorenzetti +11 more
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Influenza Virus Usurps an Interferon-Induced Translational Program to Promote Viral Replication
Proceedings, 2020 Hosts mount prudently tuned responses to viral infection in an attempt to block nearly every step of the replication cycle. Viruses must adapt to replicate in this hostile antiviral cellular state.
Mitchell P. Ledwith +11 more
doaj +1 more source
Post-transcriptional regulation of glucocorticoid function
, 2015 Glucocorticoids (GCs) are corticosteroid hormones critically involved in the homeostatic control of stress and immune responses. Endogenous GCs generally tend to support the innate immune responses while inhibiting overexpressed adaptive immune responses.
Ishmael, Faoud T. +3 more
core +1 more source
Post-translational regulation of Oct4 transcriptional activity.
PLoS ONE, 2009 Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in ...
Jonathan P Saxe +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source