Results 41 to 50 of about 492,739 (258)
Biomolecules, 2022 microRNAs are small non-coding RNAs that play a key role in regulating gene expression. These molecules exert their function through sequence complementarity with microRNA responsive elements and are typically located in the 3′ untranslated region of ...
Tânia Monteiro Marques +1 more
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Post-transcriptional regulation of proinflammatory proteins [PDF]
Journal of Leukocyte Biology, 2004 AbstractPost-transcriptional mechanisms play a critical role in regulating the expression of numerous proteins that promote inflammatory arthritis. The mRNAs encoding a subset of these proteins possess adenine/uridine-rich elements (AREs) in their 3′-untranslated regions that profoundly influence the rate at which mRNA is degraded and translated into ...
Paul, Anderson +3 more
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Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition
Non-Coding RNA, 2018 Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leading ...
Almudena Expósito-Villén +2 more
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Post-Transcriptional and Epigenetic Regulation of Estrogen Signaling
The Journal of Pharmacology and Experimental Therapeutics, 2023 Post-translational and epigenetic regulation are important mechanisms controlling functions of genes and proteins. Although the "classic" estrogen receptors (ERs) have been acknowledged to function in mediating estrogen effects via transcriptional mechanisms, estrogenic agents modulate the turnover of several proteins via post-transcriptional and post ...
Cignarella A. +4 more
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Transcription and post-transcriptional regulation of spermatogenesis [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2010 Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards
Anilkumar, Bettegowda +1 more
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Post-transcriptional regulation: The dawn of PTB [PDF]
Current Biology, 1997 The 'polypyrimidine-tract-binding protein' (PTB) participates in the control of alternative processing and translation of various RNAs, and may operate as a multifunctional regulator of tissue-specific gene expression.
Valcárcel, Juan, Gebauer, Fátima
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Post-translational regulation of Oct4 transcriptional activity.
PLoS ONE, 2009 Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in ...
Jonathan P Saxe +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Correction to: Post-Transcriptional Gene Regulation [PDF]
, 2022 The book was inadvertently published with incorrect affiliation for the authors "Katherine B. Henke, Rachel M. Miller, Rachel A. Knoener, Mark Scalf, Michele Spiniello, and Lloyd M. Smith" in the contributors' list in FM and in the metadata of chapter 12.
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Post-Transcriptional Regulation of Nutrient Transporters [PDF]
Plant Physiology, 2020 Most protein-coding genes in eukaryotes contain introns, and splicing of precursor mRNA (premRNA) is an essential step in gene expression. This posttranscriptional step of gene regulation takes place in the nucleus, is highly conserved among eukaryotes, and involves the coordinated and ...
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