Results 41 to 50 of about 694,082 (344)
Post-transcriptional regulation of proinflammatory proteins [PDF]
Journal of Leukocyte Biology, 2004 AbstractPost-transcriptional mechanisms play a critical role in regulating the expression of numerous proteins that promote inflammatory arthritis. The mRNAs encoding a subset of these proteins possess adenine/uridine-rich elements (AREs) in their 3′-untranslated regions that profoundly influence the rate at which mRNA is degraded and translated into ...
Paul A. Anderson +3 more
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Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms
Biomedicines, 2021 MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal ...
Ying-Chin Lin +4 more
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Post-transcriptional regulation in metabolic diseases [PDF]
RNA Biology, 2012 Post-transcriptional gene regulation by microRNAs (miRNAs) and RNA-binding proteins (RBPs) is central to many biological functions. Aberrant gene expression patterns underlie many metabolic diseases that represent major public health concerns and formidable therapeutic challenges.
Wook Kim, Eun Kyung Lee
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Post-transcriptional regulation of early embryogenesis [PDF]
F1000Prime Reports, 2015 Gene expression is controlled by diverse mechanisms before, during, and after transcription. Chromatin modification factors as well as transcriptional repressors, silencers, and enhancers all feed into how eukaryotes transcribe RNA in the nucleus.
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Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition
Non-Coding RNA, 2018 Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a multitude of developmental and pathological events. It is characterized by the progressive loss of cell-to-cell contacts and actin cytoskeletal rearrangements, leading ...
Almudena Expósito-Villén +2 more
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Biomolecules, 2022 microRNAs are small non-coding RNAs that play a key role in regulating gene expression. These molecules exert their function through sequence complementarity with microRNA responsive elements and are typically located in the 3′ untranslated region of ...
Tânia Monteiro Marques +1 more
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Transcription and post-transcriptional regulation of spermatogenesis [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2010 Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards
Anilkumar Bettegowda, Miles F. Wilkinson
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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
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Target mRNA abundance dilutes microRNA and siRNA activity
Molecular Systems Biology, 2010 Post‐transcriptional regulation by microRNAs and siRNAs depends not only on characteristics of individual binding sites in target mRNA molecules, but also on system‐level properties such as overall molecular concentrations.
Aaron Arvey +4 more
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sRNA scr5239 Involved in Feedback Loop Regulation of Streptomyces coelicolor Central Metabolism
Frontiers in Microbiology, 2020 In contrast to transcriptional regulation, post-transcriptional regulation and the role of small non-coding RNAs (sRNAs) in streptomycetes are not well studied. Here, we focus on the highly conserved sRNA scr5239 in Streptomyces coelicolor.
Franziska Engel +4 more
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