Results 71 to 80 of about 771,641 (331)

Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]

, 2014
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei, Kim, Yun Ju, Maizel, Alexis   +2 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. [PDF]

PLoS ONE, 2013
Post-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post ...
Lucía Spangenberg, Alejandro Correa, Bruno Dallagiovanna, Hugo Naya   +3 more
doaj   +1 more source

RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA [PDF]

, 2016
Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation.
BOZZONI, Irene, De Vito, Francesca, DEL VECCHIO, GIORGIA, Mannironi, Cecilia, PRESUTTI, Carlo, Risi, Adele, Saunders, Sita J   +6 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Regulation of gene expression by small non‐coding RNAs: a quantitative view

Molecular Systems Biology, 2007
The importance of post‐transcriptional regulation by small non‐coding RNAs has recently been recognized in both pro‐ and eukaryotes. Small RNAs (sRNAs) regulate gene expression post‐transcriptionally by base pairing with the mRNA.
Yishai Shimoni, Gilgi Friedlander, Guy Hetzroni, Gali Niv, Shoshy Altuvia, Ofer Biham, Hanah Margalit   +6 more
doaj   +1 more source

MiR-20b Down-Regulates Intestinal Ferroportin Expression In Vitro and In Vivo

Cells, 2019
Ferroportin (FPN) is the only known cellular iron exporter in mammalian. However, post-transcriptional regulation of intestinal FPN has not yet been completely understood.
Shuxia Jiang, Xi Fang, Mingni Liu, Yingdong Ni, Wenqiang Ma, Ruqian Zhao   +5 more
doaj   +1 more source

The effects of death and post-mortem cold ischemia on human tissue transcriptomes [PDF]

, 2018
Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels.
Aguet, François, Amador, Raziel, Amadoz, Alicia, Ardlie, Kristin G., Breschi, Alessandra, 1988-, Carbonell-Caballero, Jose, Curado, Joao, Dopazo, Joaquín, Ferreira, Pedro G., Godinho, Caio P. Sá, Guigó Serra, Roderic, Hidalgo, Marta R., Muñoz-Aguirre, Manuel, Nurtdinov, Ramil, Oliveira, Carla, Oliveira, Patrícia, Pervouchine, Dmitri D., Reverter, Ferran, Sammeth, Michael, Sodaei, Reza, 1988-, Sousa, Abel, Çubut, Cankut   +21 more
core   +5 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Using Boolean Networks to Model Post-transcriptional Regulation in Gene Regulatory Networks [PDF]

, 2014
Gene Regulatory Networks (GRNs) model some of the mechanisms that regulate gene expression. Among the computational approaches available to model and study GNRs, Boolean Network (BN) emerged as very success- ful to better understand both the structural ...
Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco Michele Maria, Savino, Alessandro, Ur Rehman, Hafeez, Vasciaveo, Alessandro   +5 more
core   +1 more source