Results 1 to 10 of about 625,558 (252)
Post-translational modification of RAS proteins.
Current Opinion in Structural Biology, 2021 Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS proteins integrate signals from a wide array of receptors and initiate downstream signaling through pathways that control cellular growth. RAS proteins are fundamentally binary molecular switches in which the off/on state is determined by the binding of GDP or GTP ...
S. Campbell, M. Philips
semanticscholar +3 more sources
Post translational modification of Parkin [PDF]
Biology Direct, 2017 Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known ...
J. Chakraborty +2 more
semanticscholar +4 more sources
Artificial Intelligence Transforming Post-Translational Modification Research [PDF]
BioengineeringPost-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones.
Doo Nam Kim +8 more
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Global Post-Translational Modification Discovery
Journal of Proteome Research, 2016 A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round ...
Qiyao Li +6 more
semanticscholar +3 more sources
Tyrosine Sulfation as a Protein Post-Translational Modification
Molecules, 2015 Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases.
Yuh-Shyong Yang +5 more
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Post-translational modification of PII signal transduction proteins
Frontiers in Microbiology, 2015 The PII proteins constitute one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite
Mike eMerrick
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Antioxidants, 2021 Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and ...
Mabel Buelna-Chontal +4 more
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Uncovering post-translational modification-associated protein-protein interactions.
Current Opinion in Structural Biology, 2022 In living systems, the chemical space and functional repertoire of proteins are dramatically expanded through the post-translational modification (PTM) of various amino acid residues.
Shu Wang +2 more
semanticscholar +1 more source
FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation
Cells, 2022 FIP200, also known as RB1CC1, is a protein that assembles the autophagy initiation complex. Its post-translational modifications and degradation mechanisms are unclear. Upon autophagy activation, we find that FIP200 is methylated at lysine1133 (K1133) by
Yuan Dai +5 more
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