Results 121 to 130 of about 625,558 (252)

Multiple mechanisms of growth hormone-regulated gene transcription [PDF]

, 2007
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein ...
Calinescu, Anda Alexandra, Ceseña, Teresa I., Cui, Tracy Xiao, Huo, Jeffrey S., Iñiguez Lluhí, Jorge A., Kaplani, Julianne, Kwok, Roland, Piwien Pilipuk, Graciela, Schwartz, Jessica   +8 more
core   +1 more source

Absolute quantitation of post-translational modifications [PDF]

Frontiers in Chemistry, 2014
The cell's fate is largely governed by the dynamics of cellular events, brought about by the interplay of various proteins, in which post-translational modifications (PTMs) play a key role. Therefore, a better understanding of post-translational modification is of utmost importance to a biochemist.
openaire   +3 more sources

Structural snapshots of the reaction coordinate for O-GlcNAc transferase [PDF]

, 2014
Visualization of the reaction coordinate undertaken by glycosyltransferases has remained elusive, but is critical for understanding this important class of enzyme.
Gloster, Tracey M., Jiang, Jiaoyang, Lazarus, Michael B., Vocadlo, David J., Walker, Suzanne, Whitworth, Garrett E., Zandberg, Wesley F.   +6 more
core   +1 more source

The Human Thioredoxin System: Modifications and Clinical Applications [PDF]

Iranian Journal of Basic Medical Sciences, 2011
The thioredoxin system, comprising thioredoxin (Trx), thioredoxin reductase (TrxR) and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions.
Seyed Isaac Hashemy
doaj  

Diverse regulatory manners of human telomerase reverse transcriptase

Cell Communication and Signaling, 2019
Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation,
Meng-Meng Jie, Xing Chang, Shuo Zeng, Cheng Liu, Guo-Bin Liao, Ya-Ran Wu, Chun-Hua Liu, Chang-Jiang Hu, Shi-Ming Yang, Xin-Zhe Li   +9 more
doaj   +1 more source

Association and dissociation of the GlnK-AmtB complex in response to cellular nitrogen status can occur in the absence of GlnK post-translational modification

Frontiers in Microbiology, 2014
PII proteins are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. PII proteins control the activities of a diverse range of enzymes, transcription factors and membrane transport ...
Mike eMerrick, Martha eRadchenko, Jeremy eThornton   +2 more
doaj   +1 more source

Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein

Journal of Virology
O-GlcNAcylation, a post-translational modification consisting of O-linked N-acetylglucosamine attached to serine and threonine residues, occurs in thousands of cytoplasmic, nuclear, and mitochondrial proteins but has been reported for relatively few ...
Yunliang Zhang, Bernard Moss
doaj   +1 more source

NAD+-dependent post-translational modification of Escherichia coli glyceraldehyde-3-phosphate dehydrogenase [PDF]

, 2009
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional housekeeping protein reported to be a target of several covalent modifications in many organisms.
Josefa Badia, Juan Aguilar, Laura Aguilera, Laura Baldoma, Rosa Giménez   +4 more
core   +3 more sources

Discovery and Identification of Serum Succinyl‐Proteome for Postmenopausal Women with Osteoporosis and Osteopenia

Orthopaedic Surgery, 2019
Objective For the purpose of providing evidence for the treatment of osteoporosis and osteopenia, this study retrospectively identified succinylation‐modified sites and proteins in postmenopausal women, and bioinformatics analysis were performed. Methods
Li‐li Zhang, Chun‐wen Li, Kang Liu, Zhong Liu, Bo‐cheng Liang, Yi‐ran Yang, Xiao‐lin Shi   +6 more
doaj   +1 more source

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

Scientific Reports, 2011
Post-translational modifications (PTMs) broadly contribute to the recent explosion of proteomic data and possess a complexity surpassing that of protein design.
George A. Khoury, Richard C. Baliban, C. Floudas   +2 more
semanticscholar   +1 more source