Results 11 to 20 of about 446,769 (341)
The interplay of post-translational modification and gene therapy [PDF]
Drug Design, Development and Therapy, 2016 Victor Chukwudi Osamor,1–3 Shalom N Chinedu,3,4 Dominic E Azuh,3,5 Emeka Joshua Iweala,3,4 Olubanke Olujoke Ogunlana3,4 1Covenant University Bioinformatics Research (CUBRe) Unit, Department of Computer and Information Sciences, College of Science ...
Osamor VC +4 more
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Post-translation modifications [PDF]
Current Opinion in Chemical Biology, 2009 The development of proteomics has been one of the great achievements in analytical chemical biology in the past ten years. The determination of the total protein constituents in biological samples has allowed new and unprecedented insights into cellular processes and diseases.
Lara K. Mahal, Carlito B. Lebrilla
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Post-translational Modifications of the Protein Termini [PDF]
Frontiers in Cell and Developmental Biology, 2021 Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change between the variety of proteins encoded in the genome and the variety of their biological functions ...
Chen, Li, Kashina, Anna
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Post translational modification of Parkin [PDF]
Biology Direct, 2017 Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation.
Chakraborty, Joy +2 more
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Post-translational modifications of microtubules [PDF]
Journal of Cell Science, 2010 Microtubules – polymers of tubulin – perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and ...
Dorota Wloga, Jacek Gaertig
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Post-translational modifications of tubulin [PDF]
Current Biology, 2014 Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational ...
Carsten Janke, Maria M. Magiera
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Post-translational modification by SUMO [PDF]
Toxicology, 2010 Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes.
Hannoun, Zara +4 more
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Post-Translational Modifications of Extracellular Proteasome [PDF]
Molecules, 2020 The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways in eukaryotic cells. Abnormal functioning of this system has been observed in cancer and neurological diseases. The 20S proteasomes, essential components of the UPS, are present not only within the cells but also in the extracellular space, and their concentration in
Egor E. Diakonov +6 more
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Sirtuin Oxidative Post-translational Modifications [PDF]
Frontiers in Physiology, 2021 Increased sirtuin deacylase activity is correlated with increased lifespan and healthspan in eukaryotes. Conversely, decreased sirtuin deacylase activity is correlated with increased susceptibility to aging-related diseases. However, the mechanisms leading to decreased sirtuin activity during aging are poorly understood.
Kelsey S. Kalous +2 more
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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. [PDF]
, 2015 Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes.
Caddick, S +4 more
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