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Post-translational modifications and chromatin dynamics
Essays in Biochemistry, 2019Abstract The dynamic structure of chromatin is linked to gene regulation and many other biological functions. Consequently, it is of importance to understand the factors that regulate chromatin dynamics. While the in vivo analysis of chromatin has verified that histone post-translational modifications play a role in modulating DNA ...
Thomas O. Tolsma, Jeffrey C. Hansen
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Post-Translational Modifications
1982During the past three decades there have been major improvements in the techniques for isolating and characterizing proteins. As a consequence of the application of these improved procedures it has become apparent that proteins are not simple linear polymers of amino acids but have three–dimensional structure. Many proteins consist of several component
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Post-translational Modification of Transthyretin in Plasma
Biochemical and Biophysical Research Communications, 1998To determine the behavior of transthyretin (TTR) in blood circulation, TTR purified from normal subjects' plasma was injected to rats, and blood and urine were collected time dependently. Although TTR in plasma was proven to be a predominantly cysteine (Cys) conjugated form by electrospray ionization mass spectrometry (ESI-MS) analysis, it was ...
H, Terazaki +9 more
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Post-translational Modifications in Parkinson’s Disease
2022Parkinson's disease (PD) is a complex neurodegenerative disorder characterised by progressive degeneration of the dopaminergic neurons in the substantia nigra leading to severe motor complications. The etiology of the disease is unknown with its sporadic form accounting for 90% of cases.
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Post-translational modifications of protein biopharmaceuticals
Drug Discovery Today, 2010The majority of therapeutic proteins display one or more post-translational modifications (PTMs). These modifications normally influence the biochemical and therapeutic properties of such proteins. Choosing an expression system capable of generating an appropriate product PTM profile remains one of the most crucial decisions a drug developer must make.
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Analysis of Post‐translational Modifications
PROTEOMICS, 2013René, Zahedi, Albert, Sickmann
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