Results 41 to 50 of about 446,769 (341)

Post-translational modifications of the polycystin proteins [PDF]

Cellular Signalling, 2020
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and affects up to 12 million people worldwide. Germline mutations in two genes, PKD1 or PKD2, account for almost all patients with ADPKD.
Streets, A., Ong, A.
openaire   +2 more sources

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]

, 2014
The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat, Beltran-Alvarez, Pedro, Brugada, Ramon, Chiva, Cristina, Chiva, Critina, Pagans, Sara, Perez-Serra, Alexandra, Perez-Villa, Felix, Pérez-Serra, Alexandra, Pérez-Villa, Félix, Sabido, Eduard, Sabidó, Eduard, Schulte, Uwe, Tarradas, Anna   +13 more
core   +1 more source

iProteinDB: An Integrative Database of Drosophila Post-translational Modifications

G3: Genes, Genomes, Genetics, 2019
Post-translational modification (PTM) serves as a regulatory mechanism for protein function, influencing their stability, interactions, activity and localization, and is critical in many signaling pathways.
Yanhui Hu, Richelle Sopko, Verena Chung, Marianna Foos, Romain A. Studer, Sean D. Landry, Daniel Liu, Leonard Rabinow, Florian Gnad, Pedro Beltrao, Norbert Perrimon   +10 more
doaj   +1 more source

Post-Translational Modifications of TRP Channels [PDF]

Cells, 2014
Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human. TRP channels exert a multitude of physiological functions ranging from Ca2+ homeostasis in the kidney to pain reception and vision. These channels are activated by a wide range of stimuli and
Olaf Voolstra, Armin Huber
openaire   +4 more sources

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source

Deciphering post‐translational modification codes [PDF]

FEBS Letters, 2013
Post‐translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning to be understood.
Matthew P. Torres, Adam P. Lothrop, Stephen M. Fuchs   +2 more
openaire   +3 more sources

Functional divergence in the role of N-linked glycosylation in smoothened signaling [PDF]

, 2015
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have ...
A Helenius, A Ruiz i Altaba, AG Soto, AG Soto, AH Polizio, AH Polizio, AJ Petrescu, AJ Zhu, AM Wilbanks, Angela M. Arensdorf, Ashley Truong, B Sivertsen, BJ Arey, BR Myers, C Torroja, C Wang, C Wang, CE Carroll, D Maier, D Nedelcu, D Rendie, D Shi, Daniel P. Stewart, David J. Robbins, DJ Casso, DJ Robbins, DM Stone, Edgar Angelats, F Landomiel, F Shen, G Navarro, Gemma Navarro, H Sasaki, J Alcedo, J Bischof, J Briscoe, J He, J Taipale, J Taipale, JD Violin, JJ Kovacs, JK Chen, JK Chen, Joseph T. Opferman, JP Incardona, KC Corbit, L Zhou, LW McGinnes, M Murone, M van den Heuvel, M Wheatley, MF Tansky, MT Barakat, N Denef, NA Riobo, Peter J. McCormick, PM Lanctot, PW Ingham, R Rana, R Rohatgi, R Rohatgi, R Schroder, R Schroder, R Teperino, R Xia, Rajat Rohatgi, RT Strachan, S Li, S Marada, S Mukhopadhyay, S Nachtergaele, S Nachtergaele, S Rajagopal, S Yao, Sigrid Nachtergaele, SK Ogden, Stacey K. Ogden, Suresh Marada, T Von Ohlen, V Marigo, X Lu, Y Nakano, Y Zhao, YH Belgacem   +83 more
core   +3 more sources

Citrullination Post-Translational Modification: State of the Art of Brain Tumor Investigations and Future Perspectives

Diagnostics, 2023
The present review aims to describe the state of the art of research studies investigating the citrullination post-translational modification in adult and pediatric brain tumors.
Diana Valeria Rossetti, Alexandra Muntiu, Luca Massimi, Gianpiero Tamburrini, Claudia Desiderio   +4 more
doaj   +1 more source

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]

, 2020
Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe, García Domínguez, Mario, Herrero Ruiz, Andrés M., Moreno Oñate, Marta, Ruiz Pérez, José Francisco   +4 more
core   +1 more source

Orchestrating the proteome with post-translational modifications [PDF]

Journal of Experimental Botany, 2018
Post-translational modifications (PTMs) add tremendous complexity to cellular proteomes. The large variety of these modifications and their concurrent appearance in proteins dramatically increase the proteome size from mere thousands to the order of millions of possible protein forms.
openaire   +4 more sources