The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]
, 2007 SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton +44 more
core +2 more sources
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. [PDF]
, 2009 Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular ...
Cook, Peter J +5 more
core +2 more sources
Glycan analysis of the chicken synaptic plasma membrane glycoproteins - a major synaptic N-glycan carries the LewisX determinant [PDF]
, 2005 The majority of plasma membrane components are glycosylated. It is now widely accepted that this post-translational modification is crucial during the establishment, maintenance and function of the nervous system.
Koles, Kate +3 more
core +4 more sources
Post-translational Modification-Based Regulation of HIV Replication
Frontiers in Microbiology, 2018 Human immunodeficiency virus (HIV) relies heavily on the host cellular machinery for production of viral progeny. To exploit cellular proteins for replication and to overcome host factors with antiviral activity, HIV has evolved a set of regulatory and ...
Lin Chen +2 more
doaj +1 more source
KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5 [PDF]
, 2015 KRAB-associated protein 1 (KAP1), the transcriptional corepressor of Kruppel-associated box zinc finger proteins (KRAB-ZFPs), is subjected to multiple post-translational modifications that are involved in fine-tuning of the multiple biological functions ...
Cesaro, Elena +4 more
core +2 more sources
Decoding post-translational modification for understanding stress tolerance in plant
Crop DesignPlants undergo deteriorating stress situations, which has an adverse effect on their overall growth, maturation, and development. To mitigate these situations plants undergo regulatory cellular mechanisms including epigenetic changes at both genomic as ...
Anuradha Pandey, Dipak Gayen
doaj +1 more source
Histone post-translational modification and the DNA damage response
Genes and Diseases, 2023 DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently.
Haoyun Song +6 more
doaj +1 more source
Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches [PDF]
, 2015 Microbes with the capability to survive in the host tissue and efficiently subvert its innate immune responses can cause various health hazards. There is an inherent need to understand microbial infection patterns and mechanisms in order to develop ...
Jers, Carsten +2 more
core +1 more source
Computational Identification of Post Translational Modification Regulated RNA Binding Protein Motifs. [PDF]
PLoS ONE, 2015 RNA and its associated RNA binding proteins (RBPs) mitigate a diverse array of cellular functions and phenotypes. The interactions between RNA and RBPs are implicated in many roles of biochemical processing by the cell such as localization, protein ...
Andrew S Brown +2 more
doaj +1 more source
Post-translational protein lactylation modification in health and diseases: a double-edged sword
Journal of Translational MedicineAs more is learned about lactate, it acts as both a product and a substrate and functions as a shuttle system between different cell populations to provide the energy for sustaining tumor growth and proliferation.
Hang Gong +4 more
doaj +1 more source