iPTMnet: an integrated resource for protein post-translational modification network discovery
Nucleic Acids Res., 2017 Protein post-translational modifications (PTMs) play a pivotal role in numerous biological processes by modulating regulation of protein function. We have developed iPTMnet (http://proteininformationresource.org/iPTMnet) for PTM knowledge discovery ...
Hongzhan Huang +10 more
semanticscholar +1 more source
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. [PDF]
, 2017 Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Atger, F. +14 more
core +1 more source
Archaeal S-layer glycoproteins: post-translational modification in the face of extremes [PDF]
, 2014 Corresponding to the sole or basic component of the surface (S)-layer surrounding the archaeal cell in most known cases, S-layer glycoproteins are in direct contact with the harsh environments that characterize niches where Archaea can thrive ...
Jerry Eichler, Lina Kandiba
core +2 more sources
Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches [PDF]
, 2015 Microbes with the capability to survive in the host tissue and efficiently subvert its innate immune responses can cause various health hazards. There is an inherent need to understand microbial infection patterns and mechanisms in order to develop ...
Jers, Carsten +2 more
core +1 more source
Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions. [PDF]
, 2011 BackgroundOsteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles.
Arjomandi, Mehrdad +5 more
core +7 more sources
Post-translational Modification-Based Regulation of HIV Replication
Frontiers in Microbiology, 2018 Human immunodeficiency virus (HIV) relies heavily on the host cellular machinery for production of viral progeny. To exploit cellular proteins for replication and to overcome host factors with antiviral activity, HIV has evolved a set of regulatory and ...
Lin Chen +2 more
doaj +1 more source
Synthetic post-translational modification of histones.
Current Opinion in Chemical Biology, 2018 Chromatin is the physiological template of genetic information in all eukaryotic cells, a highly organised complex of DNA and histone proteins central in regulating gene expression and genome organisation.
Simon Nadal +3 more
semanticscholar +1 more source
Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction [PDF]
, 2018 Spt6 is a histone chaperone that associates with RNA polymerase II and deposits nucleosomes in the wake of transcription. Although Spt6 has an essential function in nucleosome deposition, it is not known whether this function is influenced by post ...
Adams, Alexander T. +10 more
core +1 more source
Post-Translational Modification and Subcellular Distribution of Rac1: An Update
Cells, 2018 Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla M. Abdrabou, Zhixiang Wang
semanticscholar +1 more source
Decoding post-translational modification for understanding stress tolerance in plant
Crop DesignPlants undergo deteriorating stress situations, which has an adverse effect on their overall growth, maturation, and development. To mitigate these situations plants undergo regulatory cellular mechanisms including epigenetic changes at both genomic as ...
Anuradha Pandey, Dipak Gayen
doaj +1 more source