Results 81 to 90 of about 445,929 (364)

Tyrosine Sulfation as a Protein Post-Translational Modification

Molecules, 2015
Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases.
Yuh-Shyong Yang, Chen-Chu Wang, Bo-Han Chen, You-Hua Hou, Kuo-Sheng Hung, Yi-Chih Mao   +5 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

T-cell cytotoxicity in the absence of viral protein synthesis in target cells [PDF]

, 1977
CYTOTOXIC T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompati-bility complex (MHC) which were present during anti-viral sensitisation in ...
A Munro, A Scheid, BH Sandford, BK Ray, D Aminoff, F Garrido, GI Ada, H Ertl, ID Gardner, J Neff, J Salk, M. J. GETHING, M. WATERFIELD, U Koszinowski, U. KOSZINOWSKI, UK Laemmli, Y Hosaka, Y Ueda, YK Shimizu   +18 more
core   +1 more source

Regulation of DELLA Proteins by Post-translational Modifications [PDF]

Plant and Cell Physiology, 2020
AbstractDELLA proteins are the negative regulators of the gibberellin (GA) signaling pathway. GAs have a pervasive effect on plant physiology, influencing processes that span the entire life cycle of the plant. All the information encoded by GAs, either environmental or developmental in origin, is canalized through DELLAs, which modulate the activity ...
Noel Blanco-Touri��n, Antonio Serrano-Mislata, David Alabad�   +2 more
openaire   +5 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Computational Identification of Post Translational Modification Regulated RNA Binding Protein Motifs. [PDF]

PLoS ONE, 2015
RNA and its associated RNA binding proteins (RBPs) mitigate a diverse array of cellular functions and phenotypes. The interactions between RNA and RBPs are implicated in many roles of biochemical processing by the cell such as localization, protein ...
Andrew S Brown, Bidyut K Mohanty, Philip H Howe   +2 more
doaj   +1 more source

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury [PDF]

, 2016
It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining ...
Carter, Wayne, Ganesan, Murali, Kharbanda, Kusum, Kirpich, Irina A., McClain, Criag J., Osna, Natalie, Petersen, Dennis R., Shearn, Colin T., Tomasi, Maria L.   +8 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Post-translational Modification-Based Regulation of HIV Replication

Frontiers in Microbiology, 2018
Human immunodeficiency virus (HIV) relies heavily on the host cellular machinery for production of viral progeny. To exploit cellular proteins for replication and to overcome host factors with antiviral activity, HIV has evolved a set of regulatory and ...
Lin Chen, Oliver T. Keppler, Christian Schölz   +2 more
doaj   +1 more source

Chemical generation and modification of peptides containing multiple dehydroalanines [PDF]

, 2015
Chemical formation of dehydroalanine has been widely used for the post-translational modification of protein and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined.
Foley, PJ, Morrison, PM, Warriner, SL, Webb, ME   +3 more
core   +1 more source