Results 81 to 90 of about 468,229 (335)

Decoding post-translational modification for understanding stress tolerance in plant

Crop Design
Plants undergo deteriorating stress situations, which has an adverse effect on their overall growth, maturation, and development. To mitigate these situations plants undergo regulatory cellular mechanisms including epigenetic changes at both genomic as ...
Anuradha Pandey, Dipak Gayen
doaj   +1 more source

Global Post-Translational Modification Discovery

Journal of Proteome Research, 2017
A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance.
Qiyao Li, Michael R. Shortreed, Craig D. Wenger, Brian L. Frey, Leah V. Schaffer, Mark Scalf, Lloyd M. Smith   +6 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Post-translational protein lactylation modification in health and diseases: a double-edged sword

Journal of Translational Medicine
As more is learned about lactate, it acts as both a product and a substrate and functions as a shuttle system between different cell populations to provide the energy for sustaining tumor growth and proliferation.
Hang Gong, Huang Zhong, Long Cheng, Liang-Ping Li, De-Kui Zhang   +4 more
doaj   +1 more source

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]

, 2015
5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola, CICCARONE, FABIO, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +3 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Potential coordination role between O-GlcNAcylation and epigenetics

Protein & Cell, 2017
Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the glycoside hydrolase O-GlcNAcase (OGA) in cells. O-GlcNAcylation often occurs on serine
Donglu Wu, Yong Cai, Jingji Jin
doaj   +1 more source

Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches [PDF]

, 2015
Microbes with the capability to survive in the host tissue and efficiently subvert its innate immune responses can cause various health hazards. There is an inherent need to understand microbial infection patterns and mechanisms in order to develop ...
Jers, Carsten, Mijakovic, Ivan, Ravikumar, Vaishnavi   +2 more
core   +1 more source

Post-Translational Modifications of Exosomal Proteins

Frontiers in Immunology, 2014
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies (MVBs) upon the fusion of these ...
Olga Moreno-Gonzalo, Carolina Villarroya-Beltri, Francisco Sánchez-Madrid   +2 more
openaire   +5 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source