Results 191 to 200 of about 267,857 (250)

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Unveiling the hidden regulators: how post-translational modifications influence the progression and treatment of hepatocellular carcinoma. [PDF]

Front Oncol
Qi S, Yong X, Ding Z, Hu M, Li Y, Li L, Hu H, Tang H.   +7 more
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

The role of post-translational modifications in the dynamics of cytoplasmic biomolecular condensates in plants. [PDF]

New Phytol
Legoux M, Reichheld JP, Merret R.
europepmc   +1 more source

PolyGraph – Flexible, Biocompatible & Electrically Optimized Graphene‐Polymer Composites for Next‐Generation Neural Interfaces

Advanced Healthcare Materials, EarlyView.
PolyGraph, a flexible graphene‐polycaprolactone nanocomposite, unites conductivity, biocompatibility, and processability for next‐generation neural interfaces. Fabricated into microneedle arrays with ultra‐flexible backings, PolyGraph enables bidirectional neuronal recording and stimulation in brain tissue, advancing brain‐computer interface (BCI) and ...
Jack Maughan, Ian Woods, Cian O'Connor, Pablo Quintana‐Sarti, Eoin Caffrey, Jose M. Munuera, Tian Carey, Adrian Dervan, Alejandro López Valdés, Omar Mamad, Maeve A. Caldwell, Fergal J. O'Brien, Jonathan N. Coleman   +12 more
wiley   +1 more source

Live-cell decoding of labile post-translational modifications in APE1 with a rationally engineered nano-catcher. [PDF]

Nucleic Acids Res
Zhang R, Xie H, Zhu C, Sun Y, Li K, Li H, Niu X, Jin C, Zhao M.   +8 more
europepmc   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Post-Translational Modifications Control Phase Transitions of Tau

ACS Central Science
Wyatt C. Powell, McKinley Nahum, Karl Pankratz, Morgane Herlory, James Greenwood, Darya Poliyenko, Patrick Holland, Ruiheng Jing, Luke Biggerstaff, Michael H. B. Stowell, Maciej A. Walczak   +10 more
doaj   +1 more source

Prolyl-3-hydroxylase 1 is a central regulator of collagen post-translational modifications and the collagen biosynthetic network. [PDF]

J Biol Chem
Staab-Weijnitz CA, Merl-Pham J, Hennen E, Onursal C, Cabeza-Boeddinghaus N, Kandhari K, Stremlau M, Behr J, Hilgendorff A, Bächinger HP, Hauck SM, Vanacore R, Hansen KC, Basak T.   +13 more
europepmc   +1 more source