Results 91 to 100 of about 41,962 (282)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling

Nature Communications, 2022
Post-translational modifications (PTMs) can regulate cellular protein function but their global impact on protein turnover is largely unknown. Here, the authors develop proteomic workflows to profile PTM-resolved protein turnover and analyze the effects ...
Jana Zecha, Wassim Gabriel, Ria Spallek, Yun-Chien Chang, Julia Mergner, Mathias Wilhelm, Florian Bassermann, Bernhard Kuster   +7 more
doaj   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. [PDF]

, 2015
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium channels (Navs) is very important for the transmission of nociceptive information since they give rise to the upstroke of the action potential (AP).
Abdulla, Abrahamsen, Abriel, Abriel, Abriel, Abriel, Akopian, Akopian, Akopian, Aley, Aley, Amaya, Arévalo, Bair, Basbaum, Battaini, Ben-Johny, Bendahhou, Beneski, Bennett, Bennett, Berta, Bierhaus, Bierhaus, Bird, Bird, Biswas, Black, Black, Black, Bongiorno, Bouhassira, Bretin, Brouwer, Brower, Brüggemann, Cachemaille, Campbell, Cang, Cantrell, Cantrell, Casals-Diaz, Catterall, Catterall, Cesare, Cesare, Chahine, Chatelier, Chattopadhyay, Chen, Chen, Cheng, Chi, Ciechanover, Coggeshall, Cohen, Costa, Costa, Coward, Coward, Cox, Cronin, Cummins, Cummins, Cummins, Cusdin, Daemen, Dascal, Decosterd, Deribe, Deschênes, Deval, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dietrich, Dina, Dina, Djouhri, Dogrul, Dong, Duan, Dubin, Dustrude, Edinger, Ednie, England, Errington, Errington, Faber, Faber, Fahmi, Ferrari, Ferreira, Ferreira, Fertleman, Firsov, Fitzgerald, Fjell, Fotia, Fotia, Fukuoka, Fukuoka, Galan, Gasser, Gaudet, Gee, Gershon, Gold, Gold, Gold, Goldin, Gould, Gudes, Han, Heikamp, Henry, Herzog, Herzog, Hirade, Hiruma, Ho, Hockley, Hoeijmakers, Hoeijmakers, Huang, Hucho, Hudmon, Hunter, Ikeda, Inagaki, Isom, Isom, Isom, James, Jarecki, Jarvis, Ji, Ji, Jin, Joazeiro, Johnson, Johnson, Joshi, Julius, Kazarinova-Noyes, Kazen-Gillespie, Kerr, Khasar, Khasar, Khasar, Kim, Kispersky, Klugbauer, Kreegipuu, Kresge, Kress, Kretschmer, Kruger, Laedermann, Laedermann, Laedermann, Laedermann, Lai, Latremoliere, Leipold, Leo, Leung, Li, Liang, Liu, Liu, Liu, Liu, Liu, Lolignier, Lopez-Santiago, Lopez-Santiago, Lou, Luo, Luo, Maingret, Malhotra, Malhotra, Maltsev, Mann, Mao, Matzner, Matzner, Messner, Metzger, Millan, Minett, Mittmann, Moon, Moremen, Morgan, Mori, Murphy, Murray, Nagasako, Narayanan, Nassar, Nelson, Noda, Novella, Numann, Nuss, Obata, Olsson, Payandeh, Perry, Persson, Pertin, Petho, Pickart, Pierre, Pitchford, Plummer, Priest, Qu, Rang, Ranscht, Raymond, Recio-Pinto, Ren, Renganathan, Renganathan, Ritchie, Rossie, Rossier, Rush, Rush, Rush, Sadamasu, Sangameswaran, Sanna, Schaller, Schepelmann, Schild, Schirmeyer, Schmidt, Schmidt, Scholz, Shah, Shao, Shi, Shih, Smith, Smith, Snyder, Snyder, Solà, Souza, Stamboulian, Staub, Strickland, Stucky, Sun, Suter, Taiwo, Tan, Thakor, Theriault, Thornalley, Toledo-Aral, Toledo-Aral, Tong, Toth, Turk, Tyrrell, van Bemmelen, Vanoye, Vijayaragavan, Vijayaragavan, Vijayaragavan, von Hehn, Wada, Wada, Waechter, Wang, Waxman, Waxman, Waxman, Waxman, Way, Wells, Widmann, Woolf, Woolf, Woolf, Woolf, Woolf, Wu, Xu, Xu, Xu, Xu, Yan, Yanagita, Yanagita, Yang, Yeomans, Yin, Young, Yu, Yu, Yuhi, Zhang, Zhang, Zhang, Zhang, Zhou, Zhou, Zhuang, Zimmer, Zochodne   +318 more
core   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]

, 2019
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong, Estève, Pierre Olivier, Hansen, Ulla, Lee, Jiyoung, Pradhan, Sriharsa, Ruse, Cristian, Schaus, Scott   +6 more
core   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Developing diazirine-based chemical probes to identify histone modification ‘readers’ and ‘erasers’ [PDF]

, 2015
Post translational modifications (PTMs, e.g., phosphorylation, acetylation and methylation) of histone play important roles in regulating many fundamental cellular processes such as gene transcription, DNA replication and damage repair.
Li, X, LIU, Z, YANG, T
core   +1 more source