Results 111 to 120 of about 27,453 (249)

Tubulin Post-Translational Modifications in Cardiovascular Diseases: Emerging Mechanisms and Therapeutic Modulation by Traditional Chinese Medicine

Drug Design, Development and Therapy
Yangfan Qi,1 Yiyi Zhou,2 Xinyue Ning,1 Jiahao Ye,1,3 Zhixi Hu,1,3 Lin Li1,3 1School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Medical School, Hunan University of Chinese Medicine,
Qi Y, Zhou Y, Ning X, Ye J, Hu Z, Li L
doaj  

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication

EMBO Reports
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging infectious pathogen with a high fatality rate, is an enveloped tripartite segmented single-stranded negative-sense RNA virus.
Bingxin Liu, Xiaoyan Tian, Linrun Li, Rui Zhang, Jing Wu, Na Jiang, Meng Yuan, Deyan Chen, Airong Su, Shijie Xu, Zhiwei Wu   +10 more
doaj   +1 more source

Recent Advances in Pickering Emulsion Templated Phase Change Material Microcapsules: Design, Fabrication, and Multifunctional Applications

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fabrication process of phase change microcapsules using a Pickering emulsion template method and their subsequent applications. The increasing demand for efficient thermal energy storage systems has driven the development of phase change material microcapsules (PCMMs), which provide high energy‐storage density, reversible phase change, and reduced ...
Ziyan Li, Jinsheng Sun, Kaihe Lv, Chaozheng Liu, Meichun Li   +4 more
wiley   +1 more source

BRCT domains contain an intrinsic post‐translational modification (PTM) recognition code that affects it stability

The FASEB Journal, 2019
BRCA1 C‐terminal (BRCT) domains are protein binding modules that relay signals throughout various cellular pathways. The human genome encodes 23 BRCT‐domain containing proteins that are commonly found in tandem and have been characterized as phosphoprotein binding domains with functions throughout the DNA damage response.
openaire   +1 more source

Computational protein stability analysis of SCN1A missense variants reveals domain‐dependent stability patterns

Epilepsia Open, EarlyView.
Abstract Objective To determine whether computational protein‐stability predictions discriminate pathogenic from benign SCN1A missense variants, and to characterize the structural distribution of predicted destabilization among pathogenic variants. Methods On an AlphaFold3‐predicted Nav1.1 structure, FoldX, and Rosetta Cartesian ΔΔG were computed for a
Youngkyu Shim, Eungu Kang, Naeun Kwak, Suhyun Kim   +3 more
wiley   +1 more source

Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview

Oncogen, 2019
Prabodha K Swain, Ramtej J Verma, Jaya Bajpai, Akash P Desai, Vaishna Prabhakaran, B Sharan Sharma   +5 more
openaire   +1 more source

Majorbio Cloud 2026 Update: An End‐to‐End Solution for Proteomics Research

iMetaMed, EarlyView.
The recent upgrade of Majorbio Cloud facilitates a more streamlined and accurate research process, aiding researchers across the various proteomics subfields. Furthermore, it propels the advancement of multi‐layered, multi‐omics scientific investigations centered around proteins.
Caiping Shi, Chang Han, Jichen Han, Bing Yang, Yachen Dong, Jianhua Zhao, Binxu Liu, Rundong Fang, Wenyao Fu, Jiawen Ma, Meng Luo, Lixing Feng, Yitong Feng, Huimin Cui, Mengxi Li, Huasheng Huang, Xianglin Zhang, Kegang Yu   +17 more
wiley   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics. [PDF]

Mol Cell Proteomics, 2018
Wei L, Gregorich ZR, Lin Z, Cai W, Jin Y, McKiernan SH, McIlwain S, Aiken JM, Moss RL, Diffee GM, Ge Y.   +10 more
europepmc   +1 more source