Results 91 to 100 of about 43,191 (287)

The Role of Protein Post-Translational Modifications in Fruit Ripening

Horticulturae
Fruit ripening represents a multifaceted biological process intricately controlled by an array of plant hormones, transcription factors, and epigenetic modifications.
Ting Li, Jing Zeng, Xinquan Yang, Pedro Garcia-Caparros, Xuewu Duan   +4 more
doaj   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications

Frontiers in Immunology
Histones play crucial roles in both promoting and repressing gene expression, primarily regulated through post-translational modifications (PTMs) at specific amino acid residues.
Xiaohong Duan, Xiaohong Duan, Xiaohong Duan, Zhiyao Xing, Zhiyao Xing, Zhiyao Xing, Lu Qiao, Shan Qin, Xuejing Zhao, Yanhua Gong, Yanhua Gong, Yanhua Gong, Xueren Li, Xueren Li   +13 more
doaj   +1 more source

Characterisation of peanut allergens and possible post-translational modifications (PTMs) [PDF]

, 2018
BackgroundPeanut allergy is the most common type of food allergy causing severe reactions or even fatal anaphylaxis in sensitised individuals. The major peanut allergens are Ara h 1, Ara h 2, Ara h 3, and Ara h 6 which cause the most severe responses. Their molecular properties have been characterised but possible post-translational modifications (PTMs)
Liu, Shu-hua, Mihailović, Jelena, Smiljanić, Katarina, Epstein, Michelle M., Ćirković Veličković, Tanja   +4 more
openaire   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks [PDF]

, 2018
Integrated multiomics network analysis reveals signaling profiles in lung cancer.
Clark, Neil R., Comb, Michael, Cook, William, Foltz, Lauren, Gaiser, Jeremiah, Grimes, Mark, Hall, Benjamin, Hornbeck, Peter, Lachmann, Alexander, Levy, Tyler, Ma’ayan, Avi, Rikova, Klarisa, Smirnova, Ekaterina, Wheeler, Travis, Zhang, Bin   +14 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Distinct types of protein modifications in diabetic endothelial dysfunction

Cardiovascular Diabetology
Diabetes mellitus is a metabolic disorder characterized by persistent hyperglycemia. Chronic diabetes mellitus may contribute to endothelial dysfunction and result in various conditions such as diabetic retinopathy, diabetic nephropathy, neuropathy ...
Qianyou Zhou, Xintong Ge, Zhaojing Chen, Danyi Cao, Yun Chen, Jiahai Shi, Guoliang Meng   +6 more
doaj   +1 more source

A mass spectrometry-guided genome mining approach for natural product peptidogenomics. [PDF]

, 2011
Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes.
Cimermancic, Peter, Dorrestein, Pieter C, Fenical, William, Fischbach, Michael A, Kersten, Roland D, Moore, Bradley S, Nam, Sang-Jip, Xu, Yuquan, Yang, Yu-Liang   +8 more
core