Results 261 to 270 of about 85,477 (330)

Accelerating Characterization of Therapeutic Antibodies: A Comparative Assessment of icIEF-UV/MS and the Traditional Fractionation Workflow. [PDF]

J Am Soc Mass Spectrom
Shah A, Shah P, Johnson A, Bender J, Gumerov D, Ding J, Mack S, Stone MD, Ostrowski MA.   +8 more
europepmc   +1 more source

HLA‐A*02:01 Presents Penicillin‐Modified Cysteinylated Peptides for T Cell Recognition

Allergy, EarlyView.
We describe, for the first time, HLA presentation of benzylpenicillin‐modified peptides incorporating a cysteine‐benzylpenicillin conjugate (CysBP), disulfide linked to an in‐chain cysteine. A dominant HLA‐A*02:01 restricted benzylpenicillin‐specific T cell clone, TRAV3/TRBV20‐1 (BP‐TCR), was identified within PBMCs of a penicillin‐hypersensitive ...
Shawn J. R. Goh, Hovey H. W. Lu, Katherine E. Scull, Kirti Pandey, Mohammadreza Dorvash, Kirsten Deckert, Robert Puy, Robyn E. O'Hehir, Anthony W. Purcell, Nicole A. Mifsud, Patricia T. Illing   +10 more
wiley   +1 more source

Importance of post-translational protein modifications in PFAS toxicity. [PDF]

Toxicology
Safreena N, Chandra G, Thirumalaikumar VP, Cannon J.   +3 more
europepmc   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, EarlyView.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Short-chain acyl post-translational modifications in cancers: Mechanisms, roles, and therapeutic implications. [PDF]

Cancer Commun (Lond)
Wu T, Zhao Y, Zhang X, Wang Y, Chen Q, Zhang M, Sheng H, Zhang Y, Guo J, Li J, Fan Y, Wang Z, Li Y, Wang H, Wei M, Hu X, Wu H.   +16 more
europepmc   +1 more source

Citrullination in Tumor Metastasis, Inside and Outside the Cells

Cancer Science, EarlyView.
ABSTRACT Tumor metastasis remains a poor prognosis because it occurs in all tissues and is difficult to diagnose or prevent before metastatic tumor nodules form. Metastasis is a multi‐step process involving tumor cells, bone marrow‐derived cells, and tissue resident cells, making it a biological three‐body problem.
Takeshi Tomita, Priyanka Sharma, Sachie Hiratsuka   +2 more
wiley   +1 more source

A systematic review of protein post-translational modifications in sepsis. [PDF]

Mol Biol Rep
Yang L, Shi Z, Wang F, Shi G, Li C, Chen G.   +5 more
europepmc   +1 more source

Studying post-translational modifications with protein interaction networks

, 2014
Stelzl, U., Woodsmith, J.
core   +1 more source

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source