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A transcriptomic and proteomic map of primary human cell types. [PDF]
Mun DG +15 more
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Decoding the Post-translational Modification Crosstalk: Functional Implications of Phosphorylation, Acetylation, and Methylation. [PDF]
Qin X, Nangia S.
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POSTMan (POST‐translational modification analysis), a software application for PTM discovery
PROTEOMICS, 2009AbstractPost‐translationally modified peptides present in low concentrations are often not selected for CID, resulting in no sequence information for these peptides. We have developed a software POSTMan (POST‐translational Modification analysis) allowing post‐translationally modified peptides to be targeted for fragmentation.
Magnus Ø, Arntzen +6 more
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PTM-X: Prediction of Post-Translational Modification Crosstalk Within and Across Proteins
2022Posttranslational modifications (PTMs), which are processes of adding covalent groups in protein amino acids after the translation, play an important role in regulating proteins' localization, degradation, and functions. Different PTMs both within a single protein and across multiple proteins can work together or regulate reciprocally, known as PTM ...
Yuxuan, Li, Yuanhua, Huang, Tingting, Li
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Journal of Proteomics, 2023
Myocardial infarction (MI) leading to heart failure contributes to almost 85% of deaths associated with CVDs. MI results from plaque formation in the coronary artery which leads to a lack of oxygen and nutrients in the myocardium. To date, stenting is a widely used gold-standard technique to maintain the proper blood flow through coronary circulation ...
Vivek, Sarohi, Trayambak, Basak
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Myocardial infarction (MI) leading to heart failure contributes to almost 85% of deaths associated with CVDs. MI results from plaque formation in the coronary artery which leads to a lack of oxygen and nutrients in the myocardium. To date, stenting is a widely used gold-standard technique to maintain the proper blood flow through coronary circulation ...
Vivek, Sarohi, Trayambak, Basak
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Cancer Research, 2023
Abstract Post-translational modifications (PTMs) play key roles in regulating cell signaling in health and disease processes. Recent advances in mass spectrometry enable comprehensive investigation of PTMs. However, identifying functionally relevant PTMs and protein domains implicated in disease remains a key challenge. We present CLUMPS-
Shankara K. Anand +4 more
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Abstract Post-translational modifications (PTMs) play key roles in regulating cell signaling in health and disease processes. Recent advances in mass spectrometry enable comprehensive investigation of PTMs. However, identifying functionally relevant PTMs and protein domains implicated in disease remains a key challenge. We present CLUMPS-
Shankara K. Anand +4 more
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Study of Post-Translational Modifications (PTMs) with Max Quant software
2022Post-translational modifications are covalent processing events that alter the function of the protein by adding a modifying group to one or more amino acids. Their detection and quantification are particularly challenging. We set up parameters that allowed us to detect glycosylation and acetylation by using an Orbitrab LC-MS/MS and we processed the ...
Beatrice Aiuto +7 more
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2014
Of the 25,000-30,000 human genes, about 2 % code for proteins. However, there are about one to two million protein entities. This is primarily due to alternative splicing and post-translational modifications (PTMs). Identifying all these modifications in one proteome at a particular time point during development or during the transition from normal to ...
Armand G, Ngounou Wetie +2 more
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Of the 25,000-30,000 human genes, about 2 % code for proteins. However, there are about one to two million protein entities. This is primarily due to alternative splicing and post-translational modifications (PTMs). Identifying all these modifications in one proteome at a particular time point during development or during the transition from normal to ...
Armand G, Ngounou Wetie +2 more
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[Post-translational modification (PTM) bioinformatics in China: progresses and perspectives].
Yi chuan = Hereditas, 2015Post-translational modifications (PTMs) are essential for regulating conformational changes, activities and functions of proteins, and are involved in almost all cellular pathways and processes. Identification of protein PTMs is the basis for understanding cellular and molecular mechanisms.
Ze-xian, Liu +13 more
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