Results 151 to 160 of about 14,425,416 (299)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Skeletal and Dentoalveolar Components of Maxillary Expansion: A Systematic Review of Post-Treatment Stability. [PDF]

Children (Basel)
Cenzato N, Tremolada A, Comparini A, Zamparini F, Maspero C.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Reviewing the Department of Social and Rehabilitation Services' efforts to computerize alcohol and drug abuse treatment information

, 1995
"A report to the Legislative Post Audit Committee"--Cover.; "May 1995" ...
Foster, Allan E.
core  

The mirrored burden and accountable handovers in cancer survivorship: co‑designing a post‑treatment transition standard. [PDF]

Npj Health Syst
Kierkegaard P, Su B, Gujral D, Liesching-Schroder K, Lagergren P, McGregor A, Grayer J.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Epidemiology and treatment of post-stroke depression

, 2008
Stefano PaolucciFondazione Santa Lucia – I.R.C.C.S, Rome, ItalyAbstract: Mood depression is a common and serious complication after stroke. According to epidemiological studies, nearly 30% of stroke patients develop depression, either in the ...
Stefano Paolucci
core  

Type 2 diabetes mellitus is associated with distinct post-treatment metabolic profiles in pulmonary tuberculosis. [PDF]

Front Cell Infect Microbiol
Li X, He Z, Gao Q, Hou Z, Zhang K, Qin Z, Zheng X, Yu H, Wu J, Chen H.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Diagnostic Performance of Post-Treatment F-18 FDG PET/CT for Detecting Recurrent Cervical Cancer. [PDF]

Diagnostics (Basel)
Kim CY, Lee SW, Chong GO, Kim JM, Lee YH, Hong CM, Jeong SY.   +6 more
europepmc   +1 more source