Results 161 to 170 of about 3,176,644 (267)

Positioning siponimod and the post-treatment gap: the unmet needs of SPMS patients in Italian real-world practice. [PDF]

Ther Adv Neurol Disord
Zanghì A, Borriello G, Foschi M, Bianco A, Signoriello E, Cellerino M, Di Filippo PS, Baldisseri F, Romano G, Cicia A, Lus G, Inglese M, Mirabella M, Avolio C, D'Amico E.   +14 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Maintenance of intestinal CX3CR1⁺ macrophage homeostasis defines post-treatment control in SIV-infected macaques. [PDF]

Nat Commun
Hua S, Benmeziane K, Desjardins D, Dimant N, Leonec M, Bossevot L, Lemaitre J, Mélard A, Relouzat F, Avettand-Fenoël V, Dereuddre-Bosquet N, Sáez-Cirión A, Le Grand R, Cavarelli M.   +13 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Dynamic Association Between Health Literacy and Fear of Progression Among Nasopharyngeal Cancer Survivors During the Post‑treatment Survivorship Period: A Multicenter Exploratory Longitudinal Study. [PDF]

Patient Prefer Adherence
Lin QM, Zhang BJ, Qiu XM, Chen AY, Zhang QY, Lin BH.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Tailoring Pore Size and Surface Charge of Polyamide Reverse Osmosis Membranes via Alkaline Post-Treatment for Brackish Water Desalination. [PDF]

Polymers (Basel)
Li Y, Wang R, Liu Z, Zhao Y, Li L, Cao Q, Shao F.   +6 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Optimal post-treatment surveillance strategy for human papillomavirus-positive oropharyngeal cancer. [PDF]

Cell Rep Med
Cao C, Sherman EJ, Riaz N, McBride SM, Yu Y, Shamseddine A, Wong W, Dunn LA, Lee NY.   +8 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source