Results 171 to 180 of about 3,324,679 (315)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Post-treatment SIV control is associated with specific features of viral persistence before and after treatment interruption. [PDF]

Nat Commun
Charre C, Melard A, Chaillon A, Gardiennet E, Desjardins D, Passaes C, Millet A, Fillion M, Dimant N, Monceaux V, Dereuddre-Bosquet N, Lambotte O, Muller-Trutwin M, Rouzioux C, Le Grand R, Saez-Cirion A, Avettand-Fenoel V.   +16 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Post-treatment infection prediction in CLL using domain adaptation of lymphoma electronic health records. [PDF]

Acta Oncol
Parviz M, Brieghel C, Werling M, Lacoppidan T, Rotbain E, Niemann CU, Agius R.   +6 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

TB preventive treatment coverage among children under six years of age in TB-affected households

IJTLD Open
A. Kadam, A.H. Moe, M.S. Barthwal, G. Lele, A. Kakrani, V. Mave, N. Suryavanshi, J.E. Golub, S.R. Cox, on behelf of the TB Aftermath study team, A. Mahajan, Y. Bhosale, S. Dugga, P. Kadam, S. Jadhav, V. Bodhe, P. Bhalchim, S. Rathod, V. Dhamale, N. Sonawane, P. Ambekar, A. Bhalchim, A. Patole   +22 more
doaj   +1 more source

Positioning siponimod and the post-treatment gap: the unmet needs of SPMS patients in Italian real-world practice. [PDF]

Ther Adv Neurol Disord
Zanghì A, Borriello G, Foschi M, Bianco A, Signoriello E, Cellerino M, Di Filippo PS, Baldisseri F, Romano G, Cicia A, Lus G, Inglese M, Mirabella M, Avolio C, D'Amico E.   +14 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Maintenance of intestinal CX3CR1⁺ macrophage homeostasis defines post-treatment control in SIV-infected macaques. [PDF]

Nat Commun
Hua S, Benmeziane K, Desjardins D, Dimant N, Leonec M, Bossevot L, Lemaitre J, Mélard A, Relouzat F, Avettand-Fenoël V, Dereuddre-Bosquet N, Sáez-Cirión A, Le Grand R, Cavarelli M.   +13 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source