Results 81 to 90 of about 2,079,695 (308)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Changes in cortical activation during proprioceptive stimulation and galvanic vestibular stimulation in healthy individuals and individuals with post-stroke balance disorders: A functional near-infrared spectroscopy study

NeuroImage: Clinical
Introduction: Although previous studies have shown that galvanic vestibular stimulation (GVS) and proprioceptive stimulation (PS) can improve balance function in patients with post-stroke balance disorders, the exact central mechanisms remain unclear ...
Lixia Liu, Jingchuan He, Feiyu Nong, Yalin Huang, Shijun Huang, Xiangyu Qin, Chongwu Xiao, Yaobin Long   +7 more
doaj   +1 more source

Emotional modulation of visual cortex activity: A functional nearinfrared spectroscopy study [PDF]

, 2009
Functional neuroimaging and electroencephalography reveal emotional effects in early visual cortex. Here, we used fNIRS to examine haemodynamic responses evoked by neutral, positive and negative emotional pictures, matched for brightness, contrast, hue,
Gray, Marcus A., Jones, Catherine L., Medford, Nick, Minati, Ludovico   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex

Frontiers in Neural Circuits, 2014
The activation of the ventral tegmental area (VTA) can rebuild the tonotopic representation in the primary auditory cortex (A1), but the cellular mechanisms remain largely unknown. Here, we investigated the firing patterns and membrane potential dynamics
Yunxiao eLou, Wenzhi eLuo, Guangwei eZhang, Can eTao, Penghui eChen, Yi eZhou, Ying eXiong   +6 more
doaj   +1 more source

Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles in cardiac ventricular myocytes. Effects via modification of surface potential. [PDF]

, 1993
Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles was investigated in cardiac ventricular myocytes using the patch-clamp technique.
Ji, S, Langer, GA, Weiss, JN
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effects of Al-Ti migration-driven interfacial reactions on low-activation Al2O3/Ti brazed joints

Nuclear Engineering and Technology
Al2O3/Ti serves as a critical brazed structure in accelerator tubes. In this study, the post-irradiation activation behavior of Ag–Cu and AlMgCr filler metals was comparatively evaluated.
Kai-Yu Ou, Yuntao Song, Ji-Chao Wang, Xiancai Meng, Lizheng Liang, Ping Liu   +5 more
doaj   +1 more source