Results 61 to 70 of about 2,079,695 (308)
Masticatory biomechanics in the rabbit : a multi-body dynamics analysis [PDF]
, 2014 Acknowledgement We thank Sue Taft (University of Hull) for the µCT-scanning of the rabbit specimen used in this study. We also thank Raphaël Cornette, Jacques Bonnin, Laurent Dufresne, and l'Amicale des Chasseurs Trappistes (ACT) for providing permission
Curtis, Neil +6 more
core +5 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model
Reproductive Biology and EndocrinologyBackground Follicular loss after ovarian tissue cryopreservation and autotransplantation (OTCTP) remains a major challenge due to follicle activation and ischemia.
Jules Bindels +4 more
doaj +1 more source
Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Frontiers in Neurology, 2023 BackgroundThis study investigated the cortical activation mechanism underlying locomotor control during healthy and hemiplegic walking.MethodsA total of eight healthy individuals with right leg dominance (male patients, 75%; mean age, 40.06 ± 4.53 years)
Xiaokuo He +6 more
doaj +1 more source
MicroRNAs in melanoma development and resistance to target therapy [PDF]
, 2017 microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio +7 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Nature CommunicationsAchieving durable viral remission without antiretroviral therapy (ART) remains a central challenge in HIV-1 cure research. Using a pathogenic SIV model in male cynomolgus macaques, we investigated mucosal and systemic immune features associated with post-
Stéphane Hua +13 more
doaj +1 more source
The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]
, 2019 Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core