Results 41 to 50 of about 2,079,695 (308)

Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes

Frontiers in Immunology
BackgroundT cells drive post-stroke secondary brain injury, with the Th17/Treg balance shaping post-stroke inflammation. Soraphen A (SorA) inhibits Th17 polarization while preserving Tregs.
Juliane Gellrich, Nora Bödecker, Imke Reich, Johanna Ruhnau, Stefan Groß, Susanne H. Kirsch, Susanne H. Kirsch, Rolf Müller, Rolf Müller, Rolf Müller, Juliane Schulze, Antje Vogelgesang   +11 more
doaj   +1 more source

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Cell Communication and Signaling, 2021
Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the
Zhu Liang, Andreas Damianou, Elena Di Daniel, Benedikt M. Kessler   +3 more
doaj   +1 more source

The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]

, 2017
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P, Headrick, John P., Neumann, David L., Peart, Jason N., Shum, David H K, Stapelberg, Nicolas J C   +5 more
core   +1 more source

Post‐Activation Potentiation Increases Recruitment of Fast Twitch Fibers: A Potential Practical Application in Runners [PDF]

Journal of Human Kinetics, 2018
Abstract To determine the relationship between fatigue and post-activation potentiation, we examined the effects of sub-maximal continuous running on neuromuscular function tests, as well as on the squat jump and counter movement jump in endurance athletes.
Marco Gervasi, Anna Rita Calavalle, Stefano Amatori, Eugenio Grassi, Piero Benelli, Piero Sestili, Davide Sisti   +6 more
openaire   +3 more sources

Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian, Robert U. Newton, Dennis R. Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle‐McIntyre, Jodie Cochrane Wilkie, Daniel A. Galvão   +7 more
wiley   +1 more source

NEK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury

Frontiers in Molecular Neuroscience, 2019
As one of the most common causes of mortality and disability, traumatic brain injury (TBI) is a huge psychological and economic burden to patients, families, and societies worldwide.
Yuhua Chen, Yuhua Chen, Jiao Meng, Jiao Meng, Fangfang Bi, Fangfang Bi, Hua Li, Cuicui Chang, Chen Ji, Wei Liu   +9 more
doaj   +1 more source

In vitro cultured progenitors and precursors of cardiac cell lineages from human normal and post-ischemic hearts. [PDF]

, 2007
The demonstration of the presence of dividing primitive cells in damaged hearts has sparked increased interest about myocardium regenerative processes.
ARCUCCI, ALESSANDRO, CASTALDO, CLOTILDE, Cotrufo M, de Feo M, De Santo L, DI MEGLIO, FRANCA, Giordano Lanza G., MONTAGNANI, STEFANIA, NURZYNSKA, DARIA ANNA   +8 more
core  

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

Frontiers in Immunology, 2020
Cerebral ischemia induces a robust neuroinflammatory response that is largely mediated by the activation of CNS resident microglia. Activated microglia produce pro-inflammatory molecules to cause neuronal damage.
Ge Gao, Congcong Li, Jie Zhu, Yi Wang, Yunlong Huang, Yunlong Huang, Shu Zhao, Shiyang Sheng, Yu Song, Chenhui Ji, Chunhong Li, Xiaoyu Yang, Ling Ye, Xinrui Qi, Yanyan Zhang, Xiaohuan Xia, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng   +18 more
doaj   +1 more source