Results 141 to 150 of about 77,986 (211)

Enriched Environment Enhances Motor Function in Mice With Cerebral Infarction by Promoting mTOR‐Dependent Autophagy in the Contralateral Dentate Nucleus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Although environmental enrichment (EE) promotes post‐stroke motor recovery, the mechanisms underlying its regulation of cerebellar dentate nucleus (DN) plasticity remain unclear; this study therefore investigated how EE coordinates autophagy, mitochondrial homeostasis, and synaptic remodeling in the contralateral DN to facilitate functional ...
Chuan‐Jie Wang, Ke‐Wei Yu, Jun‐Fa Wu, Feng Tao   +3 more
wiley   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions. [PDF]

Mol Brain, 2019
Yoo KS, Lee K, Oh JY, Lee H, Park H, Park YS, Kim HK.   +6 more
europepmc   +1 more source

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source

Bi4Ti2.85Zr0.15O12/Nb: SrTiO3‐Based Artificial Optic Neuron for Synaptic Plasticity Simulation and Light‐Controlled Neuromorphic Computing

Materials Genome Engineering Advances, EarlyView.
An optoelectronic synapse based on Zr‐doped Bi4Ti3O12 exhibits learning/forgetting mimicry and achieves 94.2% accuracy on MNIST, demonstrating a novel pathway for high‐performance neuromorphic computing. ABSTRACT This study enhanced the optoelectronic properties of BIT (Bi4Ti3O12) through Zr doping at the B site, constructing an Au/Bi4Ti2.85Zr0.15O12 ...
Dongping Yang, Zhilong Chen, Zhenhua Tang, Qijun Sun, Yanping Jiang, Xingui Tang   +5 more
wiley   +1 more source

Liquid Phase Transition in the Postsynaptic Density? [PDF]

Trends Biochem Sci, 2017
Kennedy MB, Mastro TL.
europepmc   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography. [PDF]

Front Neuroanat, 2018
Chen X, Winters C, Crocker V, Lazarou M, Sousa AA, Leapman RD, Reese TS.   +6 more
europepmc   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source