Results 61 to 70 of about 82,465 (254)

Global approaches to the role of miRNAs in drug-induced changes in gene expression

Frontiers in Genetics, 2012
Neurons modulate gene expression with subcellular precision through excitation-coupled local protein synthesis, a process that is regulated in part through the involvement of microRNAs (miRNAs), a class of small noncoding RNAs. The biosynthesis of miRNAs
Jodi E Eipper-Mains, Betty A Eipper, Richard E Mains   +2 more
doaj   +1 more source

Postsynaptic densities fragment into subcomplexes upon sonication [PDF]

Molecular Brain, 2019
Postsynaptic density (PSD) fractions were isolated from rat forebrain and sonicated. Pellets from sonicated samples examined by electron microscopy revealed particles with an electron density similar to PSDs that appeared to be fragments of PSDs. Immuno-gold labeling confirmed that some of these contained PSD-95 and/or SynGAP.
Ayse Dosemeci, Jung-Hwa Tao-Cheng, Valerie Bakly, Thomas S. Reese   +3 more
openaire   +3 more sources

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Learning-induced remodelling of inhibitory synapses in the motor cortex

Open Biology
Robust structural and functional plasticity occurs at excitatory synapses in the motor cortex in response to learning. It is well established that local spinogenesis and the subsequent maintenance of newly formed spines are crucial for motor learning ...
Nishita Bhembre, Annalisa Paolino, Sooraj S. Das, Sumasri Guntupalli, Laura R. Fenlon, Victor Anggono   +5 more
doaj   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Path‐Decoupled Cation‐Eutaxy III–V van der Waals Memristive Semiconductors for Mitigating the Neuromorphic Accuracy‐Energy Trade‐off

Advanced Materials, EarlyView.
Path‐decoupled III–V van der Waals memtransistors spatially separate ionic and electronic transport to overcome the conventional trade‐off between accuracy and energy in neuromorphic hardware. Mobile K+ ions in the vdW gaps set a wide conductance window, Gmax/Gmin, while gate‐tunable hole conduction lowers programming energy, enabling reliable ...
Jihong Bae, Ji Hoon Han, Taeyoung Kim, Jongbum Won, Seokmin Park, Gyu Won Kim, Sungsoon Kim, Hong Choi, Taehoon Kim, Hong‐Sub Lee, Jae‐Hyun Lee, Young Jin Choi, Jinwoo Cheon, Wooyoung Shim   +13 more
wiley   +1 more source

Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders

Frontiers in Molecular Neuroscience, 2017
Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD).
Annalisa Alfieri, Oksana Sorokina, Annie Adrait, Annie Adrait, Annie Adrait, Costanza Angelini, Isabella Russo, Alessandro Morellato, Michela Matteoli, Michela Matteoli, Elisabetta Menna, Elisabetta Menna, Elisabetta Boeri Erba, Elisabetta Boeri Erba, Elisabetta Boeri Erba, Colin McLean, J. Douglas Armstrong, Ugo Ala, Ugo Ala, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Joseph D. Buxbaum, Alfredo Brusco, Alfredo Brusco, Yohann Couté, Yohann Couté, Yohann Couté, Silvia De Rubeis, Silvia De Rubeis, Emilia Turco, Paola Defilippi   +33 more
doaj   +1 more source

Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain

BMC Neuroscience, 2020
Background Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ ...
Jolanta L. Lundgren, Lina Vandermeulen, Anna Sandebring-Matton, Saheeb Ahmed, Bengt Winblad, Monica Di Luca, Lars O. Tjernberg, Elena Marcello, Susanne Frykman   +8 more
doaj   +1 more source

Proteomic analysis of postsynaptic density in Alzheimer's Disease [PDF]

Clinica Chimica Acta, 2013
The loss of synaptic function is a pivotal mechanism in the development of Alzheimer's Disease (AD). Structural changes and loss of plasticity in the postsynaptic density (PSD) may contribute to the pathogenesis. However, the underlying molecular events triggering synaptic dysfunction remain elusive.
Jianying, Zhou, Drew R, Jones, Duc M, Duong, Allan I, Levey, James J, Lah, Junmin, Peng   +5 more
openaire   +2 more sources

Atomically Precise Ag11 and Ag12 Nanocluster‐Assembled 2D Materials for Memristive and Neuromorphic Functionality

Advanced Materials, EarlyView.
Two‐dimensional Ag11 and Ag12 cluster‐assembled materials (CAMs) are synthesized, offering atomically precise platforms with tunable electronic properties. The resulting materials exhibit robust memristive switching and neuromorphic response, demonstrating their promise for advanced nanoelectronic and memory applications.
Noohul Alam, Towhidur Rahaman, Céline Besnard, Arnulf Rosspeintner, Latevi Max Lawson Daku, Saood Khan, Soumya Jyoti Ray, Thomas Bürgi   +7 more
wiley   +1 more source