Results 71 to 80 of about 4,580,690 (149)

Preparation of Pre- and Post-synaptic Density Fraction from Mouse Cortex

Bio-Protocol, 2013
The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Chengyong Shen, Yong-Jun Chen
doaj   +1 more source

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.

Neuron, 1999
Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor-associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form
Jian C. Tu, B. Xiao, S. Naisbitt, Joseph P. Yuan, R. Petralia, P. Brakeman, Andrew W. Doan, V. Aakalu, A. Lanahan, M. Sheng, P. Worley   +10 more
semanticscholar   +1 more source

Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors

Neuron, 2013
SUMMARY Scaffolding molecules at the postsynaptic membrane form the foundation of excitatory synaptic transmission by establishing the architecture of the postsynaptic density (PSD), but the small size of the synapse has precluded measurement of PSD ...
H. MacGillavry, Yu Song, S. Raghavachari, T. Blanpied   +3 more
semanticscholar   +1 more source

Brain-specific Angiogenesis Inhibitor-1 Signaling, Regulation, and Enrichment in the Postsynaptic Density*

Journal of Biological Chemistry, 2013
Background: BAI1 is an adhesion receptor; little is known about its signaling or localization. Results: BAI1 activates Rho in a G protein-dependent manner, binds to synaptic scaffold proteins, and is highly enriched in the postsynaptic density ...
Jason R. Stephenson, K. Paavola, Stacy A. Schaefer, B. Kaur, Erwin G. Van Meir, R. Hall   +5 more
semanticscholar   +1 more source

Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission

Journal of Neuroscience, 2013
In the postsynaptic density of glutamatergic synapses, the discs large (DLG)-membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins coordinates a multiplicity of signaling pathways to maintain and regulate synaptic transmission ...
Juliane M. Krüger, Plinio D Favaro, Ming-Na Liu, A. Kitlińska, Xiao-Jie Huang, Monika Raabe, Derya S Akad, Yanling Liu, H. Urlaub, Yan Dong, Weifeng Xu, O. Schlüter   +11 more
semanticscholar   +1 more source

Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs

Cell Reports, 2017
The PSD-95/SAPAP/Shank complex functions as the major scaffold in orchestrating the formation and plasticity of the post-synaptic densities (PSDs). We previously demonstrated that the exquisitely specific SAPAP/Shank interaction is critical for Shank ...
Jinwei Zhu, Qingqing Zhou, Yuan Shang, Hao Li, Mengjuan Peng, Xiao Ke, Zhuangfeng Weng, Rongguang Zhang, Xuhui Huang, Shawn S.C. Li, Guoping Feng, Youming Lu, Mingjie Zhang   +12 more
doaj   +1 more source

Camkii-Mediated Phosphorylation Regulates Distributions of Syngap-α1 and –α2 at the Postsynaptic Density

PLoS ONE, 2013
SynGAP, a protein abundant at the postsynaptic density (PSD) of glutamatergic neurons, is known to modulate synaptic strength by regulating the incorporation of AMPA receptors at the synapse.
Yijung Yang, J. Tao-Cheng, K. Bayer, Thomas S. Reese, A. Dosemeci   +4 more
semanticscholar   +1 more source

Proteomic Analysis of Postsynaptic Density in Alzheimer Disease

Clinica chimica acta; international journal of clinical chemistry, 2013
Background The loss of synaptic function is a pivotal mechanism in the development of Alzheimer’s Disease (AD). Structural changes and loss of plasticity in the postsynaptic density (PSD) may contribute to the pathogenesis.
Jian-Ying Zhou, Drew R. Jones, D. Duong, A. Levey, J. Lah, Jun-Min Peng   +5 more
semanticscholar   +1 more source

Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing NMDA receptors in the nucleus accumbens

Frontiers in Pharmacology, 2015
Repeated exposure to ethanol followed by withdrawal leads to the alterations in glutamatergic signaling and impaired synaptic plasticity in the nucleus accumbens (NAc) in both clinical and preclinical models of ethanol exposure.
Natalie S McGuier, Audrey E Padula, Patrick J Mulholland, Lawrence Judson Chandler   +3 more
doaj   +1 more source

Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models

Drug Design, Development and Therapy, 2014
Maowen Ba,1,* Min Kong,2,* Guozhao Ma3 1Department of Neurology, Yuhuangding Hospital, Yantai City, Shandong, People’s Republic of China; 2Department of Neurology, Yantaishan Hospital, Yantai City, Shandong, People’s Republic of China ...
Ba M, Kong M, Ma G
doaj