Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation. [PDF]
Cell Res, 2021 Bai G, Wang Y, Zhang M.
europepmc +1 more source
Neuromorphic Denoising with Fully Analog Memristive In‐Memory Computing
Advanced Intelligent Systems, EarlyView.This article borrows the concepts of episodic memory in human brains to experimentally implement a memristor‐based neuromorphic denoising process. A homogeneous memristor processing unit is experimentally demonstrated for both temporal storage and neural network computation, imitating the synapses in the human brain.
Daijing Shi +5 more
wiley +1 more source
Umbelliferone-induced recovery of postsynaptic density structure revealed by the reanalysis of public electron microscopy data. [PDF]
Appl MicroscChoi GY, Choi H, Lee S, Kweon HS.
europepmc +1 more source
Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling. [PDF]
Anesthesiology, 2022 Agarwal S +3 more
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Time‐Delayed Spiking Reservoir Computing Enables Efficient Time Series Prediction
Advanced Intelligent Systems, EarlyView.This study proposes time‐delayed spiking reservoir computing (TDSRC) for efficient time series prediction. By concatenating time‐lagged states, TDSRC constructs an expanded readout feature vector without altering internal reservoir dynamics. This approach enables highly accurate forecasting with significantly fewer neurons, providing a resource ...
Pin Jin +3 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan +6 more
wiley +1 more source
Elevated circulation postsynaptic density protein 95 as a potential biomarker for predicting the diagnosis and prognosis of acute cerebral infarction. [PDF]
BMC NeurolDong Y, He Z, Lin H, Ye Z, Qin C, Li P.
europepmc +1 more source
Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Arthritis &Rheumatology, EarlyView.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source
Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume. [PDF]
ElifeYamada R, Brandani GB, Takada S.
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British Journal of Clinical Pharmacology, EarlyView.Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto +5 more
wiley +1 more source