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Advancing Human iPSC-Derived Motor Neuron Models Using Glutamatergic Modulators for Synaptic Function Studies

Zuber B, Rostami I, Leuenberger J, Ott G, Khosrozadeh A, Diab R, Saxena S, Nevian T.   +7 more
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Detection of Spontaneous Postsynaptic Potentials

Computers and Biomedical Research, 1995
The amplitude and time course of postsynaptic potentials (PSPs) recorded by intracellular techniques contain information that allow different synaptic events to be detected. In the present paper an algorithm to detect spontaneous PSPs is described. The algorithm is based on computation of approximations of first and second derivatives of the signals ...
P J, Franaszczuk, G K, Bergey, P, Kudela
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Mechanisms of slow postsynaptic potentials

Nature, 1981
Classical views of synaptic transmission have to be modified to take account of slow postsynaptic potentials (p.s.ps), which are often mediated by novel ionic and molecular mechanisms and which are sometimes evoked by neuropeptides. Understanding slow p.s.ps will provide insights into the mechanisms of biological signal transduction and long-term ...
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Primary afferent hyperpolarization without postsynaptic potentiation

Experimental Neurology, 1973
Abstract Tetanization of a cutaneous afferent pathway does not lead to potentiation of postsynaptic activity but it produces a decrease in excitability of the pathway's central terminals and an increase in the threshold of the dorsal root reflexes evoked in the same fibers by stimulation of adjacent pathways.
E J, Carregal, B L, Crue
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Inhibitory Postsynaptic Potentials in Grasshopper Muscle

Science, 1964
Hyperpolarizing inhibitory postsynaptic potentials have been discovered in fibers of the "jumping" muscle of the grasshopper. These potentials attenuate the depolarizing excitatory postsynaptic responses. They are enhanced during depolarization of the muscle fiber with applied current and are diminished and then reversed during hyperpolarization.
P N, USHERWOOD, H, GRUNDFEST
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Simultaneous expression of excitatory postsynaptic potential/spike potentiation and excitatory postsynaptic potential/spike depression in the hippocampus

Neuroscience, 1995
Tetanic stimulation of afferents in the stratum radiatum of the CA1 area of the rat hippocampus results in long-term potentiation of excitatory synaptic responses in pyramidal cells. Previous studies have reported a greater increase in the population spike amplitude following the induction of long-term potentiation than could be accounted for by the ...
C, Bernard, H V, Wheal
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Quantum analysis of postsynaptic potentials

Neurophysiology, 1979
Basic formulations of the quantum theory for synaptic transmission are listed. Methods for determining the mean quantum content, quantum value and binomial parameters describing the amplitude distributions of the unitary and "minimal" postsynaptic potentials are discussed.
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Ion channels and postsynaptic potentials

Biophysical Chemistry, 1988
Neurotransmitters open transmembrane ion channels in target membranes. At the motor endplate, the open time of channels activated by acetylcholine determines the time course of the endplate current. Endplate channels are selective for cations and their conductance and open times are influenced by the nature of the permeating cation.
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Vestibular-evoked postsynaptic potentials in Deiters neurones

Experimental Brain Research, 1969
Stimulation of the vestibular nerve induced EPSPs monosynaptically in 29% of cat's Deiters neurones sampled on the ipsilateral side. These EPSPs started with latencies of 0.6–1.0 msec, rose sharply with a summit time of 0.5 msec and decayed exponentially with a time constant of 0.9–1.7 msec. Then amplitudes were graded finely according to the intensity
M, Ito, T, Hongo, Y, Okada
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Self-modeling structure of evoked postsynaptic potentials

Synapse, 2006
With the simplicity of the synaptic structure and physiology at neuromuscular junctions (NMJs) of crayfish and the given transmitter being released in quantal packets, a detailed assessment in the fundamental processes of chemical synaptic transmission is possible. Since the quantal event is the basic element of transmission, we consider an approach to
Kert, Viele, Mark, Lancaster, Robin L, Cooper   +2 more
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