Results 261 to 270 of about 134,202 (290)

Pentobarbital: Selective Depression of Excitatory Postsynaptic Potentials

Science, 1973
The effects of pentobarbital (Nembutal) on synaptic transmission and postsynaptic potentials were studied by the use of several invertebrate preparations. Pentobarbital selectively and reversibly depressed both excitatory postsynaptic potentials and sodium-dependent postsynaptic responses to putative excitatory transmitters without affecting either ...
J L, Barker, H, Gainer
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Postsynaptic Membrane Fusion and Long-Term Potentiation

Science, 1998
The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP.
P M, Lledo, X, Zhang, T C, Südhof, R C, Malenka, R A, Nicoll   +4 more
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Stretch-evoked excitatory postsynaptic potentials in motoneurons

Brain Research, 1971
Abstract The profile of excitatory postsynaptic potential (EPSP) produced on triceps surae motoneurons by 5 msec duration triangular wave stretch of de-efferented medial gastrocnemius (MG) and soleus (S) muscles was observed on anesthetized, spinalized cats.
D G, Stuart, W D, Willis, R M, Reinking
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Block of glutamate transporters potentiates postsynaptic excitation

Neuron, 1994
We have studied the effects of blockers of glutamate transporters on excitatory synaptic transmission to determine whether transporters increase the clearance rate of transmitter from the synaptic cleft on the millisecond time scale. The transporter blockers Li+ and THA increased the amplitude, but not the decay time, of spontaneous miniature AMPA ...
G, Tong, C E, Jahr
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Postsynaptic potentials in cat visual cortex

NeuroReport, 1992
During the investigation of visually evoked postsynaptic potentials (PSPs) of visual cortical neurons, we recorded cell activity under different levels of membrane potential. In some cases, however, dependence of these PSPs on the level of membrane polarization appears to be inconsistent with the conventional scheme. One disagreement was the reduction,
Volgushev, M., Pei, X., Vidyasagar, T., Creutzfeldt, O.   +3 more
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Postsynaptic Mechanisms Involved in Long-Term Potentiation

1990
Long-term potentiation (LTP) is a persistent enhancement of synaptic transmission observed at excitatory synapses in the mammalian hippocampus (Bliss and Lomo, 1973). This phenomenon is one of the most striking examples of synaptic plasticity in the vertebrate brain, and has been intensively studied as a model for learning and memory.
J A, Kauer, R C, Malenka, D J, Perkel, R A, Nicoll   +3 more
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Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation

Science, 2002
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically involved in long-term potentiation (LTP). Previous reports point to a presynaptic site of neurotrophin action. By imaging dentate granule cells in mouse hippocampal slices, we identified BDNF-evoked Ca 2+ transients in dendrites and ...
Yury, Kovalchuk, Eric, Hanse, Karl W, Kafitz, Arthur, Konnerth   +3 more
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Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates

Nature, 1975
IT is well documented that barbiturates dramatically prolong presynaptic inhibition1–4. Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites5–7. Since the inhibitory postsynaptic potentials (i.p.s.p.s) in hippocampal neurones are unusually large and the ...
R A, Nicoll, J C, Eccles, T, Oshima, F, Rubia   +3 more
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Unitary Excitatory Postsynaptic Potentials in Clarke's Column Neurones

Nature, 1967
IT is generally believed that synaptic transmission is effected by a quantal release of transmitter substances, such as has been demonstrated for the neuromuscular junction1. The quantal nature of synaptic transmission in the central nervous system is more difficult to investigate, one reason being that many presynaptic fibres usually contribute to the
E, Eide, L, Fedina, J, Jansen, A, Lundberg, L, Vyklický   +4 more
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Principal component analysis of minimal excitatory postsynaptic potentials

Journal of Neuroscience Methods, 1998
'Minimal' excitatory postsynaptic potentials (EPSPs) are often recorded from central neurones, specifically for quantal analysis. However the EPSPs may emerge from activation of several fibres or transmission sites so that formal quantal analysis may give false results.
A V, Astrelin, M V, Sokolov, T, Behnisch, K G, Reymann, L L, Voronin   +4 more
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