Results 271 to 280 of about 10,435,031 (361)

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu   +3 more
wiley   +1 more source

Reliable Neuromorphic and Nociceptive Behavior in Dual‐Stacked IGZO/ZrOX Resistive Random Access Memory for Transparent Memory Applications

open access: yesphysica status solidi (RRL) – Rapid Research Letters, EarlyView.
For the advancement of neuromorphic computing and bio‐integrated electronics, a dual‐stacked ITO/IGZO/ZrO2/Ti resistive random access memory (RRAM) device with oxygen vacancy engineering is demonstrated for reliable synaptic and nociceptive behavior. Gradual potentiation and depression, along with biologically inspired spike‐timing‐dependent plasticity
Seo‐Young Jo   +4 more
wiley   +1 more source

Sleep Deprivation in Rats Causes Dissociation of the Synaptic NMDA Receptor/D1 Dopamine Receptor Heterocomplex. [PDF]

open access: yesNeuroSci
Kiknadze N   +8 more
europepmc   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

open access: yesSensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He   +7 more
wiley   +1 more source

Conductive Materials and Electrical Stimulation for Auditory Restoration

open access: yesSensory Neuroscience, EarlyView.
Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao   +8 more
wiley   +1 more source

MXene‐Based Flexible Memory and Neuromorphic Devices

open access: yesSmall, EarlyView.
The unique two‐dimensional structure, excellent electrical conductivity, and diverse surface groups of MXenes have garnered significant attention. Coupled with their exceptional flexibility, MXene‐based devices hold immense potential for flexible memory and neuromorphic systems. This review comprehensively discusses the fundamentals of flexible devices,
Yan Li   +13 more
wiley   +1 more source

Molecular organization of central cholinergic synapses. [PDF]

open access: yesProc Natl Acad Sci U S A
Rosenthal JS   +10 more
europepmc   +1 more source

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