Results 41 to 50 of about 117,832 (333)

Structure of the planar cell polarity cadherins Fat4 and Dachsous1

Nature Communications, 2023
Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.
Elliot Medina, Yathreb Easa, Daniel K. Lester, Eric K. Lau, David Sprinzak, Vincent C. Luca   +5 more
doaj   +1 more source

SnapShot: p53 Posttranslational Modifications

Cell, 2008
Since p53 was cloned and subsequently characterized as a tumor suppressor more the 20 years ago, more than 40,000 publications have been published relating to this protein. A great majority of this scientific literature focuses on the intricate details of p53 regulation by posttranslational modifications.
Wei Gu, Jan-Philipp Kruse
openaire   +2 more sources

Posttranslational Modifications of Tubulin and Cilia [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Tubulin undergoes several highly conserved posttranslational modifications (PTMs) including acetylation, detyrosination, glutamylation, and glycylation. These PTMs accumulate on a subset of microtubules that are long-lived, including those in the basal bodies and axonemes. Tubulin PTMs are distributed nonuniformly.
Panagiota Louka, Jacek Gaertig, Ewa Joachimiak, Dorota Wloga   +3 more
openaire   +3 more sources

Mammalian N1-adenosine PARylation is a reversible DNA modification

Nature Communications, 2022
Poly-ADP-ribosylation (PARylation) is a well-known posttranslational modification of proteins. Here the authors show that beyond proteins also mammalian single-stranded DNA is PARylated in vitro and in vivo.
Michael U. Musheev, Lars Schomacher, Amitava Basu, Dandan Han, Laura Krebs, Carola Scholz, Christof Niehrs   +6 more
doaj   +1 more source

Posttranslational modification of plant microtubules. [PDF]

Plant Signal Behav, 2019
Microtubules in eukaryotes have a number of posttranslational modifications catalyzed by an array of enzymes. These modifications alter the properties of the microtubules and the ways in which they interact with partner proteins. In recent years many of the enzymes which modify the microtubules have been identified in animals and protozoans. Relatively
Gardiner J.
europepmc   +5 more sources

Posttranslational regulatory mechanism of PD-L1 in cancers and associated opportunities for novel small-molecule therapeutics

Acta Biochimica et Biophysica Sinica
Despite the tremendous progress in cancer research over the past few decades, effective therapeutic strategies are still urgently needed. Accumulating evidence suggests that immune checkpoints are the cause of tumor immune escape.
Cai Minchen, Xu Mengting, Yu Dianping, Wang Qun, Liu Sanhong   +4 more
doaj   +1 more source

TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]

, 2019
The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura, Battistelli, Cecilia, Bisceglia, Francesca, Marchetti, Alessandra, Montaldo, Claudia, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco, Zammataro, Agatino   +8 more
core   +1 more source

Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis [PDF]

Mediators of Inflammation, 2014
Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs). Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA). The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational ...
Burska, Agata N.; Hunt, Laura; Boissinot, Marjorie; Strollo, Rocky; Ryan, Brent J.; Vital, Ed; Nissim, Ahuva; Winyard, Paul G.; Emery, Paul; Ponchel, Frederique   +10 more
openaire   +5 more sources

The post-translational modification landscape of commercial beers

Scientific Reports, 2021
Beer is one of the most popular beverages worldwide. As a product of variable agricultural ingredients and processes, beer has high molecular complexity.
Edward D. Kerr, Christopher H. Caboche, Cassandra L. Pegg, Toan K. Phung, Claudia Gonzalez Viejo, Sigfredo Fuentes, Mark T. Howes, Kate Howell, Benjamin L. Schulz   +8 more
doaj   +1 more source

Post-Translational Modification of Lamins: Mechanisms and Functions

Frontiers in Cell and Developmental Biology, 2022
Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, regulation of cell cycle progression, regulation of spatial-
Mingyue Zheng, Guoxiang Jin, Zhongjun Zhou   +2 more
doaj   +1 more source