Results 41 to 50 of about 120,482 (333)

Post-Translational Modification of Lamins: Mechanisms and Functions

Frontiers in Cell and Developmental Biology, 2022
Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, regulation of cell cycle progression, regulation of spatial-
Mingyue Zheng, Guoxiang Jin, Zhongjun Zhou   +2 more
doaj   +1 more source

Posttranslational Modifications in Innate Immunity [PDF]

Journal of Innate Immunity, 2012
Taking into account that a large number of nascent gene translation products are subject to limited proteolytic processing, proteolysis is one of the most common PTMs and due to its irreversible nature needs to be very precisely controlled on multiple levels.
openaire   +3 more sources

Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation. [PDF]

PLoS ONE, 2010
BACKGROUND: Glyoxalase 1 (Glo1) and glyoxalase 2 (Glo2) are ubiquitously expressed cytosolic enzymes that catalyze the conversion of toxic alpha-oxo-aldehydes into the corresponding alpha-hydroxy acids using L-glutathione (GSH) as a cofactor.
Gerd Birkenmeier, Christin Stegemann, Ralf Hoffmann, Robert Günther, Klaus Huse, Claudia Birkemeyer   +5 more
doaj   +1 more source

Carbon Dioxide and the Carbamate Post-Translational Modification

Frontiers in Molecular Biosciences, 2022
Carbon dioxide is essential for life. It is at the beginning of every life process as a substrate of photosynthesis. It is at the end of every life process as the product of post-mortem decay.
Lynsay I. Blake, Martin J. Cann
doaj   +1 more source

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea, Hermeking, Heiko, Herzinger, Thomas, Hörz, Wolfram, Wolf, Dieter A.   +4 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Labeling and quantifying sites of protein palmitoylation

BioTechniques, 2004
As a reversible posttranslational modification, protein palmitoylation has the potential to regulate the trafficking and function of a variety of proteins. However, the extent, function, and dynamic nature of palmitoylation are poorly resolved because of
Renaldo C. Drisdel, William N. Green
doaj   +1 more source

TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]

, 2019
The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura, Battistelli, Cecilia, Bisceglia, Francesca, Marchetti, Alessandra, Montaldo, Claudia, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco, Zammataro, Agatino   +8 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Nervous System Cytoskeleton under Oxidative Stress

Diseases, 2013
Oxidative stress is a key mechanism causing protein aggregation, cell death and neurodegeneration in the nervous system. The neuronal cytoskeleton, that is, microtubules, actin filaments and neurofilaments, plays a key role in defending the nervous ...
John Gardiner, Robyn Overall, Jan Marc
doaj   +1 more source