Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study [PDF]
, 2017 journal ...
Ashida, Kiyoshi +7 more
core +2 more sources
A case of eosinophilic gastroenteritis with high PET-CT accumulation treated by P-CAB
Radiology Case Reports, 2021 Eosinophilic gastroenteritis (EGE) can present findings on computed tomography (CT) images that resemble malignant tumors. EGE is generally treated with systemic oral steroid administration, which is reportedly effective in relieving symptoms at least ...
Noriaki Manabe, M.D.Ph.D. +12 more
doaj +1 more source
LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux [PDF]
, 2017 HIGHLIGHTS \u2022 Monovalent cation homeostasis is dysregulated upon LETM1 depletion \u2022 K+/H+ exchange activity is decreased in LETM1 knockdown cells \u2022 LETM1 depletion results in K+ accumulation in the mitochondrial matrix \u2022 LETM1 knockdown
Andrea Mattarei +8 more
core +3 more sources
Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study [PDF]
, 2017 Objective To assess the non-inferiority of vonoprazan to lansoprazole for secondary prevention of non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulcer (PU) and the safety of vonoprazan during extended use.Design A phase 3, 24-week ...
Ashida Kiyoshi +8 more
core +2 more sources
High-Throughput Screening of Potassium-Competitive Acid Blockers
SLAS Discovery, 2012 H(+),K(+)-ATPase is a key enzyme in the process of gastric acid secretion, and proton pump inhibitors (PPIs) have been accepted as one of the most effective treatments for peptic ulcer and gastroesophageal reflux disease. To discover a novel class of PPIs, the authors screened a low-molecular-weight compound library and identified two prospective acid ...
Mitsuyo, Kondo +5 more
openaire +2 more sources
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2022 Histamine H2 receptor antagonists (H2RAs) suppress gastric acid production by blocking H2 receptors in parietal cells. Studies have shown that proton pump inhibitors (PPIs) are superior to H2RAs as a treatment for acid-related disorders, such as peptic ...
Cheol Min Shin
doaj +1 more source
Long-term follow-up of patients developing gastric mucosal lesions after initiating the potassium-competitive acid blocker vonoprazan [PDF]
Clinical EndoscopyKimitoshi Kubo, Noriko Kimura
doaj +2 more sources
Randomised clinical trial: tegoprazan, a novel potassium-competitive acid blocker, or lansoprazole in the treatment of gastric ulcer. [PDF]
Aliment Pharmacol Ther, 2020 Cho YK +24 more
europepmc +2 more sources
Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis [PDF]
, 2014 Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent reactive oxygen species as ...
Blanchard, Catlyn +15 more
core +1 more source
9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a potentially novel antiplatelet drug which antagonizes the effect of thromboxane A2 [PDF]
, 2018 Background: Currently, used oral antiplatelet drugs are both limited and associated with the risk of treatment failure/resistance. Research in this area is hence highly desired.
Applová, Lenka +8 more
core +1 more source