Results 61 to 70 of about 15,278 (270)

EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs [PDF]

, 1989
1. Intracellular recordings were obtained from neurons in layer II/III of rat frontal cortex. Single-electrode current- and voltage-clamp techniques were employed to compare the sensitivity of excitatory postsynaptic potentials (EPSPs) and ...
Hablitz, John H., Sutor, Bernd
core   +1 more source

The Future of Acid Inhibition [PDF]

, 2011
There are many unmet needs with current gastric acid suppression with proton pump inhibitors (PPIs). Recommended prescription of one standard morning dose for all patients and for all medical conditions must be scientifically inappropriate and far from ...
Tytgat, G. N. (Guido)
core   +1 more source

Treatment of Helicobacter pylori infection [PDF]

Microbiota in Health and Disease
Helicobacter pylori eradication strategies continue to adapt in response to increasing antimicrobial resistance. Among traditional regimens, bismuth-based quadruple therapy remains the most consistently effective first-line treatment, with registry data ...
T. Butler, C. Costigan, D. McNamara
doaj   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source

Protonated Form: The Potent Form of Potassium-Competitive Acid Blockers

PLoS ONE, 2014
Potassium-competitive acid blockers (P-CABs) are highly safe and active drugs targeting H+,K+-ATPase to cure acid-related gastric diseases. In this study, we for the first time investigate the interaction mechanism between the protonated form of P-CABs and human H+,K+-ATPase using homology modeling, molecular docking, molecular dynamics and binding ...
Hua-Jun Luo, Wei-Qiao Deng, Kun Zou
openaire   +4 more sources

Study of the Completion of Follow-up After Helicobacter Pylori Eradication Therapy [PDF]

, 2018
Background: Because no therapeutic regimens have an eradication rate of 100%, post-treatment evaluation is necessary to ensure that adequate eradication therapy for Helicobacter pylori has been provided. The fact that not all patients are evaluated after
Kajihara, Y. (Yusaku), Shimoyama, T. (Tadashi)   +1 more
core   +1 more source

The envenomation of general physiology throughout the last century. [PDF]

, 2017
Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Clustering of the K⁺ channel GORK of Arabidopsis parallels its gating by extracellular K⁺ [PDF]

, 2014
GORK is the only outward-rectifying Kv-like K⁺ channel expressed in guard cells. Its activity is tightly regulated to facilitate K⁺ efflux for stomatal closure and is elevated in ABA in parallel with ...
Ache, Alonso, Armstrong, Armstrong, Bauly, Bhat, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Blatt, Brearley, Canny, Chen, Clough, Deutsch, Dreyer, Eisenach, Geelen, Grabov, Grefen, Grefen, Grefen, Hamilton, Hedrich, Hille, Homann, Honsbein, Honsbein, Hosy, Hurst, Jiang, Johansson, Johansson, Karnik, Kim, Lai, Lebaudy, Leyman, Luu, Marquardt, Meckel, Meckel, Misonou, Mongrand, O'Connell, Pardo, Pristera, Roelfsema, Roelfsema, Romano, Rowley, Sokolovski, Sutter, Sutter, Tester, Thiel, Thiel, Thiel, Vergani, Vergani, Villalba, Wang, Wang, Yuasa, Zilly, Zonia   +73 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source