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IEEE Transactions on Nanobioscience, 2005
Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and ...
Stephen J, Korn, Josef G, Trapani
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Potassium channels are integral membrane proteins that selectively transport K+ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and ...
Stephen J, Korn, Josef G, Trapani
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2021
Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These alterations have been identified as crucial elements of the tumourigenic reprogramming of cells. Potassium channels may contribute to cancer initiation, malignant progression and therapy resistance of tumour ...
Katrin, Ganser +5 more
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Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These alterations have been identified as crucial elements of the tumourigenic reprogramming of cells. Potassium channels may contribute to cancer initiation, malignant progression and therapy resistance of tumour ...
Katrin, Ganser +5 more
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Mitochondrial potassium channels
IUBMB Life, 2009AbstractMitochondrial potassium channels are believed to contribute to cytoprotection of injured cardiac and neuronal tissues. The following potassium channels have been described in the inner mitochondrial membrane: the ATP‐regulated potassium channel, the large conductance Ca2+‐activated potassium channel, the voltage‐gated Kv1.3 potassium channel ...
Adam, Szewczyk +2 more
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Pharmacology of Potassium Channels
1997Publisher Summary Potassium channels represent the largest and most diverse family of ion channels. K+ channels can be divided into two groups, voltage-gated and ligand-gated channels, depending on the stimulus that triggers the conformational changes leading to channel opening. K+ channels share in common the feature of having high selectivity for K+
M L, Garcia +6 more
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Potassium channels in the vasculature
Current Opinion in Nephrology and Hypertension, 1998Many important cellular functions are regulated by vascular potassium channels, including the resting membrane potential. Recent evidence suggests that the function of these channels is altered in pathophysiological disorders of the cardiovascular system.
L H, Clapp, A, Tinker
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The Electrophysiology of Potassium Channels
1987Ethanol actions have mainly been described in terms of physicochemical membrane actions. More recently, investigators using intracellular electrophysiological recording techniques have been able to describe ethanol effects on ionic channel function.
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Presynaptic potassium channels
Current Opinion in Neurobiology, 1996The past year has witnessed some significant improvements in our understanding of the molecular diversity, subunit composition, and functional properties of K+ channels in heterologous expression systems. Immunocytochemical studies have yielded important information on the localization of K+ channel proteins to synaptic terminals in mammalian brain ...
J, Roeper, O, Pongs
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Trafficking of potassium channels
Current Opinion in Neurobiology, 2005Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the presence of two recently identified ...
Heusser, Katja, Schwappach, Blanche
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Nature Reviews Neuroscience, 2002
The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological ...
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The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological ...
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Pharmacology & Therapeutics, 1990
Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review
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Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review
openaire +2 more sources