Results 301 to 310 of about 444,617 (369)

D2 dopamine receptor activation of potassium channels in identified rat lactotrophs: whole-cell and single-channel recording

, 1991
LC Einhorn, K. A. Gregerson, Gerry S. Oxford   +2 more
openalex   +2 more sources

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Novel insights into the modulation of the voltage-gated potassium channel K_V1.3 activation gating by membrane ceramides. [PDF]

J Lipid Res
Cs Szabo B, Szabo M, Nagy P, Varga Z, Panyi G, Kovacs T, Zakany F.   +6 more
europepmc   +1 more source

Resilient Membranized Coacervates Formed through Spontaneous Wrapping of Heat‐Destabilized Lipid Bilayers around Coacervate Droplets

Advanced Science, EarlyView.
We present a universal way to wrap liposomes around coacervate droplets. Membrane‐enclosed coacervates form when heat‐destabilized liposomes are mixed with coacervates. Membranized coacervates (MCs) can survive pH and ionic strength fluctuations, osmotic stress, and low temperatures.
Sadaf Javed, Evan Spruijt
wiley   +1 more source

The potassium channel subunit K_V1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells. [PDF]

Elife
Martin HR, Lysakowski A, Eatock RA.
europepmc   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source

Quercetin is a foe in the heart by targeting the hERG potassium channel. [PDF]

Iran J Basic Med Sci
Lu Z, Li S, Wei R, Li W, Huang Y, Yang T, Yan M.   +6 more
europepmc   +1 more source

Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression

Advanced Science, EarlyView.
A novel strategy combining borate glass and ultrasound is proposed for the precise treatment of breast cancer. The locally delivered borate glass releases Ca2⁺ ions in situ, while ultrasound activates the highly expressed transient receptor potential vanilloid 2 channels in breast cancer cells. This synergistic effect induces specific calcium overload,
Haihong Zhu, Liping Ouyang, Yangguang Huang, Ji Tan, Chunyu Liu, Qian Wang, Rongkun Huang, Wing Tak Wong, Xuanyong Liu, Haobo Pan, Yun Liao   +10 more
wiley   +1 more source

XEN1101, a novel potassium channel opener: hope or hype for adults with focal seizure. [PDF]

Ann Med Surg (Lond)
Fareed A, Sohail A, Siddiqui W, Asif MI, Fadlalla Ahmed TK.   +4 more
europepmc   +1 more source