Investigating the Selectivity of KcsA Channel by an Image Charge Solvation Method (ICSM) in Molecular Dynamics Simulations [PDF]
, 2015 In this paper, we study the selectivity of the potassium channel KcsA by a recently developed image-charge solvation method(ICSM) combined with molecular dynamics simulations. The hybrid solvation model in the ICSM is able to demonstrate atomistically the function of the selectivity filter of the KcsA channel when potassium and sodium ions are ...
arxiv +1 more source
The persistent question of potassium channel permeation mechanisms [PDF]
arXiv, 2021 Potassium channels play critical roles in many physiological processes, providing a selective permeation route for K+ ions in and out of a cell, by employing a carefully designed selectivity filter, evolutionarily conserved from viruses to mammals. The structure of the selectivity filter was determined at atomic resolution by x-ray crystallography ...
arxiv
Feshbach resonances in potassium Bose-Bose mixtures [PDF]
Phys. Rev. A 98, 062712 (2018), 2018 We present a detailed study of the scattering properties of ultracold mixtures of bosonic potassium atoms. We locate 20 previously unobserved Feshbach resonances in isotopic 39K-41K mixtures. These are assigned to s-wave molecular channels by comparison to an asymptotic bound state model and coupled channels calculations. Additional Feshbach resonances
arxiv +1 more source
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
, 2005 We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK +7 more
core +1 more source
Mechanism of resveratrol-induced relaxation in the human gallbladder
BMC Complementary and Alternative Medicine, 2017 Background Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Resveratrol produces relaxation of vascular smooth muscle and may prevent cardiovascular diseases.
Ching-Chung Tsai +4 more
doaj +1 more source
Monte Carlo study of gating and selection in potassium channels [PDF]
Physical Review E 84, 021920, 2011, 2011 The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles. The mechanism of gating and selection of ionic species is not clearly understood.
arxiv +1 more source
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
, 2006 KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
AM Evans +23 more
core +3 more sources
Macrodipoles of potassium and chloride ion channels as revealed by electronic structure calculations [PDF]
Journal of Molecular Structure (Theochem) 950 (2010) 79-82, 2009 With the aid of quantum mechanical calculations we investigate the electronic structure of the full length (FL) potassium channel protein, FL-KcsA, in its closed conformation, and the electronic structure of the ClC chloride channel. The results indicate that both ion channels are strongly polarized towards the extracellular region with respect to the ...
arxiv +1 more source
Effect of an autism-associated KCNMB2 variant, G124R, on BK channel properties
Current Research in Physiology, 2022 BK K+ channels are critical regulators of neuron and muscle excitability, comprised of a tetramer of pore-forming αsubunits from the KCNMA1 gene and cell- and tissue-selective β subunits (KCNMB1-4).
Hans J. Moldenhauer +4 more
doaj
Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Nature Communications, 2022 The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the ...
Purushotham Selvakumar +10 more
doaj +1 more source