Results 51 to 60 of about 3,141,750 (349)

The conduction pore of a cardiac potassium channel. [PDF]

, 1998
Ion channels form transmembrane water-filled pores that allow ions to cross membranes in a rapid and selective fashion. The amino acid residues that line these pores have been sought to reveal the mechanisms of ion conduction and selectivity. The pore (P)
Goldstein, SA, Tai, KK
core  

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. [PDF]

, 2012
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying ...
Cao, Xu, Cui, Yuanyuan, Wang, KeWei, Yang, Fan, Yarov-Yarovoy, Vladimir, Zheng, Jie   +5 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]

, 2009
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Andres-Enguix, Ashmole, Ashmole, Ben-Abu, Bichet, Boeckmann, Brickley, Carter, Chemin, Colquhoun, Colquhoun, Colquhoun, Cordero-Morales, Czirják, Czirják, D. V. Vavoulis, De La Cruz, Doyle, Duprat, Fanjul, Fersht, Gao, Goldstein, Han, Han, Hidalgo, Horovitz, I. Ashmole, J. F. Feng, Jiang, Jiang, Kim, Kim, Kim, Kuo, Leonoudakis, Lopes, Lopes, Lopes, M. J. Sutcliffe, Millar, Morton, P. J. Stansfeld, P. R. Stanfield, Patel, Puja R. Mehta, Rajan, Sigworth, Stanfield, Stansfeld, Talley, Talley, Veale, Washburn, Yellen, Yuill, Yuill, Zilberberg   +57 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes [PDF]

, 1993
Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of a guanine nucleotide binding (G) protein-activated K+ channel. Current through the channel could be activated by acetylcholine or, if RNA encoding a neuronal 5HT1A receptor ...
Dascal, Nathan, Davidson, Norman, Lester, Henry A., Lim, Nancy F., Schreibmayer, Wolfgang, Wang, Weizhen   +5 more
core   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Erratum

Clinical Pharmacology: Advances and Applications, 2012
Barrese V, Miceli F, Soldovieri MV, Ambrosino P, Iannotti FA, Cilio MR, Taglialatela M. Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clinical Pharmacology: Advances and Applications.
Barrese V, Miceli F, Soldovieri MV, Ambrosino P, Iannotti FA, Cilio MR, Taglialatela M   +6 more
doaj  

Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel

Frontiers in Physiology, 2018
In human cardiac ventricular myocytes, caveolin-3 functions as a scaffolding and regulatory protein for signaling molecules and compartmentalizes ion channels.
Ravi Vaidyanathan, Louise Reilly, Lee L. Eckhardt   +2 more
doaj   +1 more source