Results 61 to 70 of about 3,141,750 (349)

Identification of MicroRNA–Potassium Channel Messenger RNA Interactions in the Brain of Rats With Post-traumatic Epilepsy

open access: yesFrontiers in Molecular Neuroscience, 2021
Background: Dysregulated expression of microRNAs and potassium channels have been reported for their contributions to seizure onset. However, the microRNA–potassium channel gene interactions in traumatic brain injury-induced post-traumatic epilepsy (PTE)
Zheng Li   +16 more
doaj   +1 more source

Biology of the KCNQ1 Potassium Channel

open access: yes, 2014
Ion channels are essential for basic cellular function and for processes including sensory perception and intercellular communication in multicellular organisms.
G. Abbott
semanticscholar   +1 more source

Slo1 is the principal potassium channel of human spermatozoa

open access: yeseLife, 2013
Mammalian spermatozoa gain competence to fertilize an oocyte as they travel through the female reproductive tract. This process is accompanied by an elevation of sperm intracellular calcium and a membrane hyperpolarization.
N. Mannowetz   +4 more
semanticscholar   +1 more source

What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation?

open access: yesAdvanced Biology, EarlyView.
The article explores the discovery of unusually large, ring‐shaped ESCRT protein structures formed by immune and stromal cells. It investigates their formation, composition, and potential roles in immune synapse formation. The findings challenge assumptions about their function in immunological synapses, suggesting an exclusive role in maintaining ...
Anthi Psoma   +3 more
wiley   +1 more source

TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes

open access: yesScientific Reports, 2017
Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F)G representing the ionic selectivity filter.
Michael E. Steinmann   +4 more
doaj   +1 more source

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

open access: yeseLife, 2022
Structures of the human lysosomal K+ channel transmembrane protein 175 (TMEM175) in open and closed states revealed a novel architecture lacking the canonical K+ selectivity filter motif present in previously known K+ channel structures.
SeCheol Oh   +7 more
doaj   +1 more source

Comparison of Mitochondrial Adenosine Triphosphate–Sensitive Potassium Channel High- vs Low-Affinity Sulfonylureas and Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With Metformin [PDF]

open access: gold, 2022
Mengting Wang   +9 more
openalex   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

open access: yesAdvanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams   +7 more
wiley   +1 more source

Potassium channel-based optogenetic silencing

open access: yesNature Communications, 2018
Optogenetic tools enable precise experimental control of the behaviour of cells. Here, the authors introduce a genetically-encoded two-protein system that enables silencing of excitable cells such as neurons and cardiomyocytes using blue light, and ...
Yinth Andrea Bernal Sierra   +18 more
doaj   +1 more source

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]

open access: yes, 2005
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia   +18 more
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