Results 61 to 70 of about 441,914 (371)

Vibrational excitons in ionophores: Experimental probes for quantum coherence-assisted ion transport and selectivity in ion channels [PDF]

Ziad Ganim et al 2011 New J. Phys. 13 113030, 2011
Despite a large body of work, the exact molecular details underlying ion-selectivity and transport in the potassium channel have not been fully laid to rest. One major reason has been the lack of experimental methods that can probe these mechanisms dynamically on their biologically relevant time scales.
arxiv   +1 more source

On ionic conduction in potassium channels [PDF]

Proceedings of the National Academy of Sciences, 2010
In ref. 1, we presented an alternative mechanism for conduction of K+ in K+ channels where site vacancies are involved, and we proposed that coexistence of several ion permeation mechanisms is energetically possible. Specifically, we found that conduction can be described as a more anarchic phenomenon than previously habitually characterized by the ...
Carmen Domene, Carmen Domene, Simone Furini   +2 more
openaire   +4 more sources

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

On the selectivity of KcsA potassium channel: asymptotic analysis and computation [PDF]

Phys. Rev. E 100, 022406 (2019), 2019
Potassium (K$^+$) channels regulate the flux of K$^+$ ions through cell membranes and plays significant roles in many physiological functions. This work studies the KcsA potassium channel, including the selectivity and current-voltage (IV) relations. A modified Poisson-Nernst-Planck system is employed, which include the size effect by Bikerman model ...
arxiv   +1 more source

A Twist on Potassium Channel Gating [PDF]

Cell, 2010
The selectivity filter of potassium channels, the narrowest segment of the pore, permits only potassium ions to diffuse through the pore. Clarke et al. (2010) now present 11 structures of an inwardly rectifying potassium channel, providing evidence that the selectivity filter functions in channel gating and conformational changes in the cytoplasmic ...
Lily Yeh Jan, Wei Zhou
openaire   +3 more sources

Shielding resources for four common radiopharmaceuticals utilized for imaging and therapy: Tc‐99m, F‐18, I‐131, and Lu‐177

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction The use of radioactive materials in the United States has been tightly regulated by the Nuclear Regulatory Commission and other entities for many decades. In 2015, however, the Joint Commission began to require hospital‐based nuclear medicine departments to conduct shielding designs and evaluations for radioactive material areas ...
Michael Oumano, Richard Wendt, James Botti, Nathan Busse, David Hintenlang, Stephanie Leon, Kevin Little, Melissa Martin, Richard Massoth, Kenneth Matthews, Rameshwar Prasad, Sharon White, Jessica Clements   +12 more
wiley   +1 more source

Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel

Frontiers in Physiology, 2018
In human cardiac ventricular myocytes, caveolin-3 functions as a scaffolding and regulatory protein for signaling molecules and compartmentalizes ion channels.
Ravi Vaidyanathan, Louise Reilly, Lee L. Eckhardt   +2 more
doaj   +1 more source

Identification of MicroRNA–Potassium Channel Messenger RNA Interactions in the Brain of Rats With Post-traumatic Epilepsy

Frontiers in Molecular Neuroscience, 2021
Background: Dysregulated expression of microRNAs and potassium channels have been reported for their contributions to seizure onset. However, the microRNA–potassium channel gene interactions in traumatic brain injury-induced post-traumatic epilepsy (PTE)
Zheng Li, Zheng Li, Yixun Ma, Yixun Ma, Fengjuan Zhou, Fengjuan Zhou, Xiao Jia, Xiao Jia, Jingjing Zhan, Jingjing Zhan, Huachao Tan, Huachao Tan, Xu Wang, Xu Wang, Tiantong Yang, Tiantong Yang, Quan Liu   +16 more
doaj   +1 more source

Targeting potassium channels in cancer [PDF]

The Journal of General Physiology, 2014
Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. Aberrant potassium channel functions contribute to diseases such as epilepsy, cardiac arrhythmia, and neuromuscular symptoms collectively known as channelopathies. Increasing evidence suggests
Xi Huang, Lily Yeh Jan
openaire   +4 more sources

Regulating Protein Immobilization During Cell‐Free Protein Synthesis in Hyaluronan Microgels

Advanced Biology, EarlyView.
Bifunctional microgels carrying a linear DNA template and Ni2+‐activated NTA moieties are used as platform for cell‐free protein synthesis and in situ protein immobilization. By varying the concentration of NTA moieties in the microgels, the amount of GFP‐His immobilized inside the microgel and released to the microgel environment can be regulated ...
Anika Kaufmann, Kateryna Ivanova, Julian Thiele   +2 more
wiley   +1 more source