Results 71 to 80 of about 2,855,994 (337)
Effect Of Site Selective Ion Channel Blocking on Action Potential [PDF]
arXiv, 2018 In this work we have theoretically investigated how the action potential generation and its associated intrinsic properties are affected in presence of ion channel blockers by adapting Gillepie's stochastic simulation technique on a very basic neuron of Hodgkin-Huxley type.
arxiv
Correlation studies of open and closed states fluctuations in an ion channel: Analysis of ion current through a large conductance locust potassium channel [PDF]
, 2001 Ion current fluctuations occurring within open and closed states of large conductance locust potassium channel (BK channel) were investigated for the existence of correlation. Both time series, extracted from the ion current signal, were studied by the autocorrelation function (AFA) and the detrended fluctuation analysis (DFA) methods.
arxiv +1 more source
Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy
Science Translational Medicine, 2012 Light-activated gene therapy acutely suppresses seizures, and gene therapy with a potassium channel prevents epileptogenesis and treats established epilepsy in a rodent model.
R. Wykes +9 more
semanticscholar +1 more source
A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings
Micromachines, 2020 Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano +6 more
doaj +1 more source
Sonochemical Functionalization of Glass
Advanced Functional Materials, EarlyView.A new method for functionalizing glass using ultrasonication of aryl diazonium salts. Aryl radicals generated by ultrasounds react with glass, forming a stable, covalently bonded organic film. The functionalized glass adheres microorganisms such as microalgae, fungi, and bacteria, suggesting potential applications in enzyme production, filtration ...
Tiexin Li +13 more
wiley +1 more source
Enhancement of Kv1.3 Potassium Conductance by Extremely Low Frequency Electromagnetic Field [PDF]
arXiv, 2015 Theoretical and experimental evidences support the hypothesis that extremely low-frequency electromagnetic fields can affect voltage-gated channels. Little is known, however, about their effect on potassium channels. Kv1.3, a member of the voltage-gated potassium channels family originally discovered in the brain, is a key player in important ...
arxiv
Chronic pain as a manifestation of potassium channel-complex autoimmunity
Neurology, 2012 Objective: Autoantibodies targeting voltage-gated potassium channel (VGKC) complexes cause a spectrum of neuronal hyperexcitability disorders. We investigated pain as a manifestation of VGKC-complex autoimmunity.
C. Klein +4 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2019 Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane,
Alisha L. Nabel +9 more
doaj +1 more source
A novel potassium channel in photosynthetic cyanobacteria. [PDF]
PLoS ONE, 2010 Elucidation of the structure-function relationship of a small number of prokaryotic ion channels characterized so far greatly contributed to our knowledge on basic mechanisms of ion conduction.
Manuela Zanetti +10 more
doaj +1 more source
Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy
Advanced Functional Materials, EarlyView.MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee +6 more
wiley +1 more source