Results 71 to 80 of about 3,061,692 (322)
A Twist on Potassium Channel Gating [PDF]
Cell, 2010 The selectivity filter of potassium channels, the narrowest segment of the pore, permits only potassium ions to diffuse through the pore. Clarke et al. (2010) now present 11 structures of an inwardly rectifying potassium channel, providing evidence that the selectivity filter functions in channel gating and conformational changes in the cytoplasmic ...
Lily Yeh Jan, Wei Zhou
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Frontiers in Molecular Neuroscience, 2021 Background: Dysregulated expression of microRNAs and potassium channels have been reported for their contributions to seizure onset. However, the microRNA–potassium channel gene interactions in traumatic brain injury-induced post-traumatic epilepsy (PTE)
Zheng Li +16 more
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Biology of the KCNQ1 Potassium Channel
, 2014 Ion channels are essential for basic cellular function and for processes including sensory perception and intercellular communication in multicellular organisms.
G. Abbott
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Targeting potassium channels in cancer [PDF]
The Journal of General Physiology, 2014 Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. Aberrant potassium channel functions contribute to diseases such as epilepsy, cardiac arrhythmia, and neuromuscular symptoms collectively known as channelopathies. Increasing evidence suggests
Xi Huang, Lily Yeh Jan
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Clinical Pharmacology: Advances and Applications, 2012 Barrese V, Miceli F, Soldovieri MV, Ambrosino P, Iannotti FA, Cilio MR, Taglialatela M. Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clinical Pharmacology: Advances and Applications.
Barrese V +6 more
doaj
Frontiers in Physiology, 2018 In human cardiac ventricular myocytes, caveolin-3 functions as a scaffolding and regulatory protein for signaling molecules and compartmentalizes ion channels.
Ravi Vaidyanathan +2 more
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Fast inactivation in Shaker K+ channels. Properties of ionic and gating currents. [PDF]
, 1998 Fast inactivating Shaker H4 potassium channels and nonconducting pore mutant Shaker H4 W434F channels have been used to correlate the installation and recovery of the fast inactivation of ionic current with changes in the kinetics of gating current known
Bezanilla, F +4 more
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Scientific Reports, 2017 Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F)G representing the ionic selectivity filter.
Michael E. Steinmann +4 more
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eLife, 2022 Structures of the human lysosomal K+ channel transmembrane protein 175 (TMEM175) in open and closed states revealed a novel architecture lacking the canonical K+ selectivity filter motif present in previously known K+ channel structures.
SeCheol Oh +7 more
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Inactivation of Kv2.1 Potassium Channels [PDF]
Biophysical Journal, 1998 We report here several unusual features of inactivation of the rat Kv2.1 delayed rectifier potassium channel, expressed in Xenopus oocytes. The voltage dependence of inactivation was U-shaped, with maximum inactivation near 0 mV. During a maintained depolarization, development of inactivation was slow and only weakly voltage dependent (tau = 4 s at 0 ...
Stephen W. Jones +5 more
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