Effect Of Site Selective Ion Channel Blocking on Action Potential [PDF]
arXiv, 2018 In this work we have theoretically investigated how the action potential generation and its associated intrinsic properties are affected in presence of ion channel blockers by adapting Gillepie's stochastic simulation technique on a very basic neuron of Hodgkin-Huxley type.
arxiv
Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model [PDF]
, 2013 The role of potassium channels in nociceptive activity was proposed in the past decade. Various type of potassium channel has been found to exert different action in propogation of action potential in nervous system.
Akhtar, Muhammad Nadeem +4 more
core
Calcium Ions Regulate K+ Uptake into Brain Mitochondria: The Evidence for a Novel Potassium Channel [PDF]
, 2009 The mitochondrial response to changes of cytosolic calcium concentration has a strong impact on neuronal cell metabolism and viability. We observed that Ca2+ additions to isolated rat brain mitochondria induced in potassium ion containing media a ...
Adam Szewczyk +43 more
core +3 more sources
Enhancement of Kv1.3 Potassium Conductance by Extremely Low Frequency Electromagnetic Field [PDF]
arXiv, 2015 Theoretical and experimental evidences support the hypothesis that extremely low-frequency electromagnetic fields can affect voltage-gated channels. Little is known, however, about their effect on potassium channels. Kv1.3, a member of the voltage-gated potassium channels family originally discovered in the brain, is a key player in important ...
arxiv
Renal potassium channels: An overview [PDF]
Kidney International, 1995 The introduction of the patch-clamp technique by Neher and Sackmann [1, 2] has led to the successful exploration of potassium (K) channels in the kidney, allowing the definition of their properties, localization along the nephron and their regulation [3–6].
openaire +2 more sources
MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. [PDF]
, 2001 The subthreshold, voltage-gated potassium channel of skeletal muscle is shown to contain MinK-related peptide 2 (MiRP2) and the pore-forming subunit Kv3.4.
Abbott, GW +5 more
core
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. [PDF]
, 2000 The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and ...
BENTON +14 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2019 Coincidence detector neurons of the medial superior olive (MSO) are sensitive to interaural time differences in the range of a few tens of microseconds. The biophysical basis for this remarkable acuity is a short integration time constant of the membrane,
Alisha L. Nabel +9 more
doaj +1 more source
ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling [PDF]
, 2019 Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form
Cui, Jianmin +4 more
core +1 more source
Activation of KATP channels in pain modulation: a systematic review of preclinical studies
Frontiers in PhysiologyObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich +3 more
doaj +1 more source