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Strategies for prolonging ventricular action potential duration without increasing transmural dispersion of repolarization. [PDF]
Physiol RepCabo C.
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Diuretic action of potassium channel blockers
European Journal of Clinical Pharmacology, 1993The availability of specific potassium channel blockers has made it possible to examine their effects along the nephron on fluid and electrolyte excretion. Recent experiments indicate that they modulate transepithelial sodium and potassium transport. In the thick ascending limb, potassium channel blockers, by interfering with potassium recycling across
Giebisch G
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Benzopyran sulfonamides as KV1.5 potassium channel blockers
Bioorganic and Medicinal Chemistry Letters, 2007K(V)1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K(V)1.5 blockers.
Tram Huynh +2 more
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Atrial-Selective Potassium Channel Blockers
Cardiac Electrophysiology Clinics, 2016Atrial fibrillation (AF) is associated with increased morbidity and mortality. Atrial-selective potassium (K(+)) channel blockers may represent a novel therapeutic target. The best validated atrial-specific ion currents are the acetylcholine-activated inward-rectifier K(+) current IK,ACh and ultrarapidly activating delayed-rectifier K(+) current IKur ...
Voigt, Niels, Dobrev, Dobromir
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Potassium channel blockers and neuronal function
Pfl�gers Archiv European Journal of Physiology, 1989This paper discusses potassium channel blockers and neuronal function.
Harvey, Alan L. +2 more
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Mechanism of Proarrhythmic Effects of Potassium Channel Blockers
Cardiac Electrophysiology Clinics, 2016Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers ...
Skibsbye, Lasse, Ravens, Ursula
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Proteinase inhibitor homologues as potassium channel blockers
Nature Structural & Molecular Biology, 1994We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints.
J M, Lancelin +4 more
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The Interactions Between hERG Potassium Channel and Blockers
Current Topics in Medicinal Chemistry, 2009The human ether-a-go-go related gene (hERG) potassium channel is critical to the QT interval in the human heart measured by the electrocardiogram (ECG). The blockade of hERG would induce undesired lethal arrhythmia, named torsades de pointes (TdP), a rare but life-threatening symptom.
Lupei, Du, Minyong, Li, Qidong, You
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Predictive models for hERG potassium channel blockers
Bioorganic & Medicinal Chemistry Letters, 2005We report here a general method for the prediction of hERG potassium channel blockers using computational models generated from correlation analyses of a large dataset and pharmacophore-based GRIND descriptors. These 3D-QSAR models are compared favorably with other traditional and chemometric based HQSAR methods.
CIANCHETTA, GIOVANNI +6 more
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