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Guidelines for Potassium Channel Blocker Use
Cardiac Electrophysiology Clinics, 2016This article summarizes recommendations for the clinical use of antiarrhythmic drugs for the treatment and prevention of atrial and ventricular arrhythmias based on current guideline and consensus documents. The choice of antiarrhythmic drug is based on the efficacy and safety profile and influenced by the presence or absence of structural heart ...
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Bupivacaine is an effective potassium channel blocker in heart
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1988The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. The effective concentrations, particularly for IK, are similar to those which depress the sodium conductance. Potassium channel block may thus contribute to bupivacaine's reported cardiotoxicity.
K R, Courtney, J J, Kendig
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Potassium channel blockers as immunosuppressants
Expert Opinion on Therapeutic Patents, 2005Recent advances in the biology of potassium channels have raised their profile as therapeutic targets for immunosuppression. Selective blockade of the intermediate-conductance calcium-activated potassium channel KCa3.1, and in particular, the voltage-gated potassium channel, Kv1.3 holds great promise in the modulation of different subsets of ...
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Potassium channel blockers as antiarrhythmic drugs
Drug Development Research, 1994AbstractSelective prolongation of cardiac repolarization is an effective means of suppressing a variety of cardiac arrhythmias, particularly those arising from a re‐entrant mechanism. Over the past several years, a variety of novel compounds have been discovered that increase cardiac action potential duration without slowing conduction.
Thomas J. Colatsky, Thomas M. Argentieri
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Compared toxicity of the potassium channel blockers, apamin and dendrotoxin
Toxicology, 1995The central toxicities of two potassium ion channel blockers, apamin and alpha-dendrotoxin (DTx), have been compared. Both apamin and dendrotoxin injected intracerebroventricularly produced signs of poisoning, including tremor and ataxia; however, only DTx produced changes in brain electrical activity, with high voltage spikes and epileptiform activity
G, Lallement +8 more
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Modeling the binding modes of Kv1.5 potassium channel and blockers
Journal of Molecular Graphics and Modelling, 2008The ultra-rapid delayed rectifier potassium current (I(Kur)), encoded by Kv1.5 gene, is the critical determinant of Phase I repolarization of action potential duration (APD). The evidences that Kv1.5 gene expresses more extensively in human atrial myocytes than in ventricle and the I(Kur) currents has not been recorded in the human ventricle, suggest ...
Qian, Yang +4 more
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Calcium- and potassium-channel blockers interact with α-adrenoceptors
Molecular and Cellular Endocrinology, 1980The so-called calcium antagonist D-600 and agents that enhance the influx of calcium ions into nerve terminals during action potentials (4-aminopyridine, tetraethylammonium, guanidine) interact with alpha-adrenoceptors. The interaction was revealed by binding experiments in vitro with the alpha 2- and alpha 1-specific ligands [3H]clonidine and [3H ...
H, Glossmann, R, Hornung
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Effects of potassium channel blockers on differentiation ofDictyostelium discoideum
Pflügers Archiv, 1989Introduction The cellular slime mold Dictyostelium discoideum is a widely used system for the study of cellular differentiation. In the so-called vegetative stage the free living amoebae feed on bacteria and divide by binary fission. However, when the food supply is exhausted, the cells aggregate under control of the secreted chemo-attractant, cyclic ...
B, Van Duijn +2 more
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Potassium Channel Blockers as Antiarrhythmic Agents
2011This article highlights the development of potassium channel blockers as antiarrhythmic agents. The chemical structures, the structure–activity relationships (SARs) of related potassium channel blockers, and their possible binding modes reported so far in literatures and patents are summarized and evaluated.
Qidong You, Qian Yang, Xiaojian Wang
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Potassium Channel Blockers: Could They Work in Alzheimer Disease?
Alzheimer Disease & Associated Disorders, 1991Many of the actions of potassium channel blockers, such as 4-aminopyridine, appear to complement the deficits in Alzheimer disease. The two clinical studies in the literature are contradictory, so potassium channel blockers may still merit trial in Alzheimer disease.
E J, Wiseman, L F, Jarvik
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