Results 151 to 160 of about 396,791 (317)

Potency Unassigned [PDF]

, 2020
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties. [PDF]

ACS Med Chem Lett
Mahmood SU, Boddu RK, Eberhard J, Hoffman CS, Gordon J, Colussi D, Childers W, Amurrio E, Danaher M, Kelly MP, Rotella DP.   +10 more
europepmc   +1 more source

Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis

, 2012
Gamma Chi, Alexandra Manos‐Turvey, P. D. T. O’Connor, Jodie M. Johnston, Genevieve L. Evans, Edward N. Baker, Richard J. Payne, J. Shaun Lott, Esther M. M. Bulloch   +8 more
openalex   +1 more source

Revisiting Chest X-ray potency as a gold standard candidate for early screening of clinical diagnosis for COVID-19 infection

, 2022
Kohar Hari Santoso, Mochamad Bachtiar Budianto, Agung Setiawan, Wiwit Nurwidyaningtyas   +3 more
openalex   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Real-World Treatment Patterns and Determinants of Therapy in Pediatric Atopic Dermatitis: A 10-Year Experience from a Tertiary Referral Center in Thailand. [PDF]

Children (Basel)
Yusakda N, Techasatian L, Asawasakulchokedee P, Uppala R, Sitthikarnkha P, Saengnipanthkul S, Sirikarn P, Kosalaraksa P.   +7 more
europepmc   +1 more source

Quantitative structure–mesothelioma potency model optimization for complex mixtures of elongated particles in rat pleura: A retrospective study

, 2016
Philip M. Cook, Joseph Swintek, Timothy D. Dawson, David J. Chapman, Mathew A. Etterson, Dale J. Hoff   +5 more
openalex   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Trends in 1-year persistence and adherence among initiators of high-potency, weight loss-indicated glucagon-like peptide 1 receptor agonists. [PDF]

J Manag Care Spec Pharm
Marshall LZ, Gleason PP, Friedlander N, Farley J, Urick BY.   +4 more
europepmc   +1 more source