Results 241 to 250 of about 583,846 (360)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Novel In Vitro Potency Assay Demonstrating the Anti-Fibrotic Mechanism of Action of CDCs in Deramiocel. [PDF]

Biomedicines
Li Y, Nice JB, Kozinova M, Adachi S, Marbán L, Elliott K, Sun M.   +6 more
europepmc   +1 more source

Effect of acetazolamide on the anticonvulsant potency of several antiepileptic drugs in mice.

, 1983
Juichi Sato, Masanori Nioka, Eiji Owada, Keiji Ito, TOSHIRO MURATA   +4 more
openalex   +2 more sources

Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis

British Journal of Pharmacology, 2017
Theerut Luangmonkong, S. Suriguga, E. Bigaeva, M. Boersema, D. Oosterhuis, K. D. de Jong, D. Schuppan, H. Mutsaers, P. Olinga   +8 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Structural insights into endogenous agonist selectivity of aminergic receptors from the octopamine β₂ receptor. [PDF]

PNAS Nexus
Hori T, Katsura K, Miyamoto-Kohno S, Uchikubo-Kamo T, Yonemochi M, Shirouzu M.   +5 more
europepmc   +1 more source

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Journal of Virology, 2015
N. Doria-Rose, J. Bhiman, Ryan S Roark, Chaim A. Schramm, J. Gorman, G. Chuang, M. Pancera, Evan M. Cale, Michael J. Ernandes, M. Louder, M. Asokan, R. Bailer, A. Druz, Isabella R. Fraschilla, N. Garrett, Marissa C. Jarosinski, R. Lynch, K. Mckee, S. O'Dell, A. Pegu, S. Schmidt, Ryan P. Staupe, Matthew S. Sutton, Keyun Wang, C. K. Wibmer, B. Haynes, S. Abdool-Karim, L. Shapiro, P. Kwong, P. Moore, L. Morris, J. Mascola   +31 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Structural Rationalization of IPMK Inhibitor Potency. [PDF]

J Med Chem
Wang H, Shears SB, Blind RD.
europepmc   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source