Results 1 to 10 of about 469,402 (307)
Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines [PDF]
Vaccines, 2023 There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present ethical concerns. The development of relevant in vitro assays is part of the solution.
Jason Szeto +17 more
doaj +2 more sources
Utilisation of monoclonal antibodies in the single radial immunodiffusion assay to determine potency and stability for seasonal and pandemic influenza vaccines [PDF]
Frontiers in ImmunologyIntroductionFollowing manufacture, influenza vaccines are required to undergo potency testing as part of the release process to market. The single radial immunodiffusion (SRID) assay is currently the compendial standard for determining the antigen ...
Jesse Bodle +6 more
doaj +2 more sources
Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). [PDF]
, 2013 Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased
Armstrong, Stephen P +4 more
core +15 more sources
Building Biomimetic Potency Tests for Islet Transplantation [PDF]
Diabetes, 2021 Diabetes is a disease of insulin insufficiency, requiring many to rely on exogenous insulin with constant monitoring to avoid a fatal outcome. Islet transplantation is a recent therapy that can provide insulin independence, but the procedure is still limited by both the availability of human islets and reliable tests to assess their function.
Aaron L. Glieberman +3 more
openaire +2 more sources
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2020 Introduction: In addition to low reproducibility, in vivo potency tests used in the quality control of immunobiological products require too many animals, causing them significant pain and suffering.
Wildeberg Cal Moreira +4 more
doaj +7 more sources
Vaccines, 2022 Inactivated vaccines are the main influenza vaccines used today; these are usually presented as split (detergent-disrupted) or subunit vaccines, while whole-virus-inactivated influenza vaccines are rare. The single radial immune diffusion (SRD) assay has
Chung Y. Cheung +8 more
doaj +1 more source
Potency of Veterinary Rabies Vaccines Marketed in Sri Lanka
Vaccines, 2023 Seven brands of veterinary rabies vaccines are commercially available in Sri Lanka, but there is no established procedure to test the potency of the vaccines at the local level, especially prior to their release.
Hasanthi Rathnadiwakara +5 more
doaj +1 more source
Assay of Diphtheria Vaccine Potency by Intradermal Challenge Test
Эпидемиология и вакцинопрофилактика, 2023 Relevance. Modern identifying potency (immunogenicity) of diphtheria toxoid tests are based on determining immunized animals resistance for administration challenge toxin or evaluation of protective antibodies level in serum.
E. I. Komarovskaya, О. V. Perelygyna
doaj +1 more source
Vaccines, 2020 High-quality vaccines are crucial to prevent infectious disease outbreaks in the poultry industry. In vivo vaccination tests are routinely used to test poultry vaccines for their potency, i.e., their capacity to induce protection against the targeted ...
Robin H. G. A. van den Biggelaar +3 more
doaj +1 more source
Vaccines, 2020 Since 2015, outbreaks of foot-and-mouth disease (FMD) in the Middle East have been caused by a new emerging viral lineage, A/ASIA/G-VII. Invitro vaccine matching data indicated that this virus poorly matched (low r1-value) with vaccines that were being ...
Aldo Dekker +7 more
doaj +1 more source