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Potency Tests of Combination Vaccines [PDF]
Clinical Infectious Diseases, 2001 Combination vaccines differ from single-component vaccines in composition and in how they are manufactured, which poses significant challenges to implementing effective quality-control tests, including measurement of potency. Because each combination vaccine is unique, existing guidelines often fail to provide sufficient information to overcome the ...
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A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS
British Journal of Anaesthesia, 1989 The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415 ...
J D, McKenzie, P, Calow, W S, Nimmo
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Skin Sensitization Testing in Potency and Risk Assessment [PDF]
Toxicological Sciences, 2001 The purpose of this article is to review, and make recommendations for, the use of relevant skin sensitization test methods, for the purposes of determination of relative potency and the threshold dose necessary for the induction of skin sensitization, and for risk assessment.
Kimber, I. +11 more
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PLoS ONE, 2021 IntroductionAntibiotics are commonly used for the treatment and prevention of bacterial infections. The potency of antibiotics can be affected by factors such as temperature, light, moisture, and storage conditions.
Demelash Demissie +3 more
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Potency testing of cell and gene therapy products
Frontiers in Medicine, 2023 Potency is one of the critical quality attributes of biological medicinal products, defining their biological activity. Potency testing is expected to reflect the Mechanism of Action (MoA) of the medicinal product and ideally the results should correlate with the clinical response.
Paula Salmikangas +4 more
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Microtitration of Rubella Virus in Monovalent Vaccinal Products [PDF]
Iranian Journal of Public Health, 2011 Background: Potency test for control of rubella vaccine is a significant factor to qualify production line and vaccination program. For this reason, WHO recommends to use the microtitration method by both vaccine companies and control laboratories ...
F Esna-Ashari +9 more
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African Scientific Reports, 2023 Diabetes is a medical condition in which the body cannot produce enough insulin to process the glucose in the blood. Type 2 diabetes is mostly diagnosed in order adults but it is increasingly seen in children, adolescent and younger adult.
Charity Ebelechukwu Okorie +1 more
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Comparative Assessment of the Whole-cell Pertussis Vaccine Potency Using Serological and Intracerebral Mouse Protection Methods [PDF]
Archives of Razi Institute, 2019 One of the most important QC tests of whole-cell pertussis vaccine (WCPV) is potency test. In this regard, mouse protection test (MPT) is the current potency method, which is associated with severe animal distress and large variability in results.
D. Mohammadbagher, M. Noofeli, G. Karimi
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Biomolecules, 2023 Prediction of the potency of bioactive compounds generally relies on linear or nonlinear quantitative structure–activity relationship (QSAR) models. Nonlinear models are generated using machine learning methods.
Tiago Janela +2 more
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Egyptian Journal of Forensic Sciences, 2016 Indian legal system makes it mandatory to medically examine any accused of rape as well as other forms of sexual assault. Accused is brought in the police custody for conducting medical examination which includes general physical examination, potency ...
Md Shadab Raheel +4 more
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