Results 201 to 210 of about 247,875 (263)

Publisher Correction: Elucidating the relationship between affinity and potency in the performance of therapeutic IgE. [PDF]

Sci Rep
Marano F, McKenzie C, Birtley JR, Hussain SA, Macleod O, Goodacre A, Wu S, Amin OE, Faulkner N, Devlin J, Regan L, Soni K, Johnson RM, Pye VE, Wilson T, Hardaker E, FitzGerald K.   +16 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Monoclonal Antibody ELISA-Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines. [PDF]

Influenza Other Respir Viruses
Odin M, Schmeisser F, Soto J, Weir JP.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-<i>N</i>-methyl-<i>N</i>-isopropyltryptamine and Related Analogs. [PDF]

ACS Chem Neurosci
Glatfelter GC, Schalk SS, Walther D, Maitland AD, Gonzalez NR, Partilla JS, Anas NA, Chadeayne AR, Naeem M, Manke DR, McCorvy JD, Baumann MH.   +11 more
europepmc   +1 more source

A Cell-Based Potency Assay for Determining the Relative Potency of Botulinum Neurotoxin A Preparations Using Manual and Semi-Automated Procedures. [PDF]

Toxins (Basel)
Dunning FM, Hendrickson S, Wolfe S, Harding D, Geurs T, Piazza TM, Little TA, Tucker WC.   +7 more
europepmc   +1 more source

Evaluation of Antiplasmodial Activity of Quinoline Derivatives Incorporating Arylnitro and Aminochalcone Moieties. [PDF]

Pharmaceuticals (Basel)
Ariefta NR, Beteck RM, Legoabe LJ, Nishikawa Y.   +3 more
europepmc   +1 more source

Vacuolar iron export alters the synergy between doxycycline and fluconazole by affecting cidal ROS levels in <i>Candida albicans</i>. [PDF]

mBio
Van Genechten W, Holtappels M, De Jonge M, Vergauwen R, Cornips G, Van Dijck P.   +5 more
europepmc   +1 more source

BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase. [PDF]

Int J Mol Sci
Jelińska J, Józwiak M, Szeleszczuk Ł, Sikora K, Kamysz W, Kleczkowska P, Gackowski M, Grodner B.   +7 more
europepmc   +1 more source

Interpretable machine learning-driven QSAR modeling for coagulation factor X inhibitors: from molecular descriptors to predictive potency. [PDF]

J Comput Aided Mol Des
Kaya AO.
europepmc   +1 more source