Results 211 to 220 of about 241,473 (261)
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Potency testing of acellular pertussis vaccines
Vaccine, 1992The laboratory assessment of the potential of acellular pertussis vaccines to protect against human disease is a major problem. The mouse intracerebral challenge test, which is the accepted potency assay for whole cell pertussis vaccines, is not suitable for testing acellular vaccines, and more recently developed murine respiratory infection assays ...
A, Robinson, S G, Funnell
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Potency Testing of Live Measles Vaccine
Archives of Pediatrics & Adolescent Medicine, 1962The preceding series of papers has furnished information pertaining to the number of infectious units of attenuated measles virus needed to immunize susceptible children. These presentations have also touched on the question of the optimum virus content of the live vaccine, both as it leaves the hands of the manufacturer and at the actual moment of ...
H M, MEYER +3 more
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American Journal of Veterinary Research, 1972
SUMMARY A relationship was shown to exist between agglutination titers and immunologic responses of cattle vaccinated with experimentally produced and commercially available Clostridium chauvoei-containing bacterins. The immunity of vaccinated and control cattle was challenged with C. chauvoei spore F.
M E, Macheak, K D, Claus, S E, Maloy
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SUMMARY A relationship was shown to exist between agglutination titers and immunologic responses of cattle vaccinated with experimentally produced and commercially available Clostridium chauvoei-containing bacterins. The immunity of vaccinated and control cattle was challenged with C. chauvoei spore F.
M E, Macheak, K D, Claus, S E, Maloy
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Comparisons of outlier tests for potency bioassays
Pharmaceutical Statistics, 2019SummaryPotency bioassays are used to measure biological activity. Consequently, potency is considered a critical quality attribute in manufacturing. Relative potency is measured by comparing the concentration‐response curves of a manufactured test batch with that of a reference standard. If the curve shapes are deemed similar, the test batch is said to
Perceval Sondag +4 more
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Simple potency test for LH-RH preparations
Journal of Biological Standardization, 1980Proestrous rats, pretreated with fluphenazine dihydrochloride (FD) to block ovulation, were used to compare the ovulation-inducing activity of two synthetic LH-RH preparations; one was received from the National Institute for Biological Standards and Control labelled Gonadorelin acetate (77/596) and the other one was prepared in Ayerst Research ...
U K, Banik, M L, Givner
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Proposed Potency Testing of Smallpox Vaccine
The Journal of Immunology, 1961Summary and Conclusions From the results of the studies described here, it is obvious that immediate application of titration in rabbit kidney tissue culture is a valid measure of smallpox vaccine potency only for the virus strain and passage levels employed.
V J Cabasso, I F Moore, M R Stebbins
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Improved potency test for live avian encephalomyelitis vaccines
Research in Veterinary Science, 1986Potency tests were carried out on live avian encephalomyelitis virus (AEV) vaccines. Vaccines were titrated in chick embryo brain cell cultures using an indirect fluorescent antibody test just before vaccination. Groups of chickens were inoculated orally with graded doses of each vaccine. After three weeks serum was taken from the chickens and examined
R A, Nicholas +4 more
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A potency test for live Newcastle disease vaccines
Journal of Biological Standardization, 1980The potency of live Newcastle disease vaccines was assessed by means of a multi-point challenge assay in vaccinated chicks. The assay was shown to give reproducible results and to be capable of detecting significant differences between the protective capacities of various vaccines.
D H, Thornton, C N, Hebert
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Relative mutagenic potencies determined in the micronucleus test
Journal of Theoretical Biology, 1978Abstract Data from two publications which include dose-response data were subject to model fitting using a Poisson distribution and a linear dose-response function. In Swiss mice, acetylaminofluorene was the weakest mutagen tested. Aflatoxin B 1 , 3-methylcholanthrene and dimethylnitrosamine were 66, 14, and 140 times as potent, respectively.
M A, Friedman +3 more
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