Results 121 to 130 of about 20,735,341 (389)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Two-phase potential flow [PDF]
Some features of two recent approaches of two-phase potential flow are presented. The first approach is based on a set of progressive examples that can be analyzed using common techniques, such as conservation laws, and taken together appear to lead in ...
Wallis, Graham B.
core +1 more source
Maps and fields with compressible density [PDF]
, 2003 Properties of steady compressible flow for which geometric constraints have been placed on the potential function are derived, under hypotheses on the flow density and the singular set.
Otway, Thomas H.
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Pressure and Velocity Profiles over a Weir Using Potential Flow Model
FluidsA potential flow model of the semi-inverse type is proposed to simulate flow over round crested weirs. This technique involves the construction of only streamlines over the weir instead of constructing the entire flow net.
M. R. Ajith Kumar +2 more
doaj +1 more source
Transactions of the Canadian Society for Mechanical Engineering, 1999 This paper presents an analytical solution for potential cross-flow in doubly-periodic in-line and staggered tube banks. The solution, in the form of a power series for the complex potential, is consistent with the well-known solution for a single cylinder.
openaire +3 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Spectral multigrid methods with applications to transonic potential flow [PDF]
Spectral multigrid methods are demonstrated to be a competitive technique for solving the transonic potential flow equation. The spectral discretization, the relaxation scheme, and the multigrid techniques are described in detail.
Hussaini, M. Y. +2 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source